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ability to perform, understand, and communicate GPCR pharmacology data analysis to a high level, as well

September 2022 GASP1 enhances malignant phenotypes of breast cancer cells and decreases their response Here, we demonstrated that GASP1 was highly expressed in breast cancers, and patients harboring altered cancer cells, such as inhibition of cell proliferation, colony formation, migration, invasion and xenograft Besides, we found that GASP1 knockout obviously improved the response of breast cancer cells to paclitaxel Collectively, this study demonstrates that GASP1 enhances malignant behaviors of breast cancer cells

September 2022 Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration "Kisspeptin is an anti-metastatic mediator in many cancer types, acting through However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic In KISS1R overexpressing triple-negative breast cancer (TNBC) cells, stimulation has been associated further investigation and may enable further stratification of the ability of kisspeptin to influence breast

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways and predicts poor patient outcomes "Triple-negative breast cancer (TNBC) is a particularly aggressive It is generally considered that TNBC is an estrogen-independent breast cancer, while a new estrogen receptor significantly linked to the worse survival in patients with lymph node metastasis, TNM stage III as well

< GPCR News < GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools cancer cells. cancer cells. cancer cells. cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression

cancer cell proliferation by enhancing the ERK pathway Published date January 2, 2023 Abstract “ Vasoactive However, the pathophysiological role of increased VIPR2 in the proliferation of breast cancer cells remains In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a cancer , Cell proliferation , ERK , GPCR , VIPR2 , cAMP.

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells lactate and 3D growth in breast cancer spheroids. Conclusions: GPR81 supports breast cancer aggressiveness, and in MCF-7 cells, this occurs at least in