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< GPCR News < GPCRs in Oncology and Immunology Molecular characterization of breast cancer cell pools cancer cells. cancer cells. cancer cells. cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen receptor alpha , gene expression

cancer cell proliferation by enhancing the ERK pathway Published date January 2, 2023 Abstract “ Vasoactive However, the pathophysiological role of increased VIPR2 in the proliferation of breast cancer cells remains In this study, we found that VIPR2 overexpression in MCF-7 and MDA-MB-231 cells, human breast cancer Increased VIPR2 also exacerbated intraperitoneal proliferation of breast cancer MDA-MB-231 cells in a cancer , Cell proliferation , ERK , GPCR , VIPR2 , cAMP.

< GPCR News < GPCRs in Oncology and Immunology Lactate receptor GPR81 drives breast cancer growth and Methods: GPR81 was stably knocked down (KD) in MCF-7 human breast cancer cells which were subjected to Key findings were additionally studied in other breast cancer cell lines and in mammary epithelial cells lactate and 3D growth in breast cancer spheroids. Conclusions: GPR81 supports breast cancer aggressiveness, and in MCF-7 cells, this occurs at least in

the NPYRs to interrogate their functional relevance in breast cancer. cancer cell lines MDA-MB-231 and MCF7. proliferation, cell migration and invasion, and spheroid growth and invasion. There were some discrepancies in the responses of each cell line to the isoform-specific antagonists Tags Breast cancer , GPCR , Hypoxia , NPY , Neuropeptide .

Oncology and Immunology Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer Published date November 1, 2022 Abstract Background: Breast cancer is the second leading cause Furthermore, proteases have an integral role in cell proliferation and growth because the proteolysis cancer initiation and progression. Tags Breast cancer; EGFR; ERAD; RHBDF2; TACE; iRhom2.

guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells Published date January 10, 2024 Abstract "G protein-coupled receptor 30 (GPR30), also named and the β1-adrenergic receptor (β1AR) are G protein-coupled receptors (GPCR) that are implicated in breast cancer progression. MCF7 breast cancer cells express GPR30, β1AR, MAGUKs, and AKAP5 in the plasma membrane, and co-immunoprecipitation

GPCRs in Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cancer into multimeric complexes larger than dimers in MDA-MB-231 human breast cancer cells and in HCC4006 human lung cancer cells. than in COS-7 and CHO cells and in a ligand-dependent manner. These results suggest that CXCR4-β2AR heteromers are present in human cancer cells and that GPCR multimerization

overexpressed in various types of cancer and is involved in several cancer phenotypes including tumor Here, we show that HRH1 is widely expressed in various cancer cell lines and cancer tissues and that coexpression of CXCR4 and HRH1 is associated with poor prognosis in breast cancer. while histamine alone does not induce cell migration. Enhanced calcium signaling and cell migration are also observed in NCI-H23 and HeLa cells, which coexpress

cancer cell lines showed that the GPR143-ESCRT pathway promotes secretion of exosomes that carry unique cell motility/invasion through the integrin/FAK/Src pathway. cell motility. " Authors Yu Jin Lee , Kyeong Jin Shin , Hyun-Jun Jang , Jin-Sun Ryu , Chae Young Lee Hoon Huh , Sun-Young Kong , Taejoon Kwon , Pann-Ghill Suh , Young Chan Chae Tags GPR143 , HRS , MVB , breast cancer , exosomal protein sorting , exosome biogenesis , melanoma , metastasis .

CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers Likewise, lysophosphatidic acid receptor 1 (LPA1) is implicated in cancer cell proliferation and migration breast cancer cell line MDA-MB-231. LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express MDA-MB-231 cells but not in LPA1-deficient cells.

GPCR News < GPCRs in Oncology and Immunology Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion Published date March 21, 2023 Abstract " Pancreatic ductal adenocarcinoma (PDAC) continues cell-specific expression and the strongest impact on overall survival. cell invasion. biology , cell biology , human.

RGS5 expression in the triple-negative (TNBCs) and non-triple-negative breast cancers (Non-TNBCs) was The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs In contrast, in the context of breast cancer tissues, the role of RGS5 was completely disrupted. RGS5 expression was increased in the triple-negative breast cancer (TNBC) tissues and in the tumor blood cancer , Regulator of G protein signaling 5 , Vascular remodeling , Vascular smooth muscle cells Source

< GPCR News < GPCRs in Oncology and Immunology GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer Published date March 11, 2023 Abstract belongs to the G protein-coupled receptor superfamily, which responds to external stimuli and regulates cancer progression, but its role in colorectal cancer (CRC) remains unclear. In the present study, expression analyses of GPR176 are performed in patients with colorectal cancer.

A3 Adenosine Receptors in Cancer Cell Lines Published date September 7, 2023 Abstract "A3 adenosine receptor is an interesting target that showed controversial roles in cancer. Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative Karl-Norbert Klotz , Sabrina Pacor , Stefano Moro , Giampiero Spalluto Tags A3 adenosine receptor , Cancer

< GPCR News < GPCRs in Oncology and Immunology Chemokine Physiology in Cancer Published date November Chemokines are chemotactic cytokines whose canonical functions govern movement of receptor expressing cells cancer cells out of the tumor as well as immigration of tumor infiltrating immune cells that culminate therapies in cancer. Authors Donovan Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration;

Research, 2014) and GPCRs (Feigin, et al., PNAS, 2014) in breast cancer pathogenesis, using mouse models coupled receptors (GPCRs) in breast cancer, and his interest in pancreatic cancer. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its He also discussed his work on G-protein coupled receptors (GPCRs) in breast cancer, identifying GPR161 as a potential drug target due to its high expression in triple negative breast cancer.

and Immunology Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. prior study, we reported the synergistic cytotoxic effects of gemcitabine and trabectedin on pancreatic cancer cells. analysis was performed, and a system pharmacodynamics model (SPD) was developed to capture pancreatic cancer

and cancer immunotherapy failure Published date June 12, 2023 Abstract "Immune checkpoint blockade ( ICB) targeting PD-1 and CTLA-4 has revolutionized cancer treatment. However, many cancers do not respond to ICB, prompting the search for additional strategies to achieve Here, we cross-integrated large singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer types and identified an enrichment of Gαs-coupled GPCRs on exhausted CD8+ T cells.

GPCRs in Oncology and Immunology Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells Published date June 29, 2023 ! Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News Call for GPCR

cells by targeting PAR-1 Published date June 21, 2024 Abstract "We have purified Peptidase M84 from This metallo-protease had no discernible impact on normal cell survival, but it specifically induced apoptosis in ovarian cancer cells. PAR-1, a GPCR which is reported to be overexpressed in ovarian cancer cells, was identified as a target This evoked apoptotic death of the ovarian cancer cells through the intrinsic route.

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by Epithelial ovarian cancer (EOC) is a leading cause of death among gynecological malignancies. In comparison, NPFF and NPFFR2 expression levels were higher in SKOV3 cells than in CaOV3 or OVCAR3 cells Treatment of SKOV3 cells with NPFF did not affect cell viability and proliferation but stimulated cell Fang , Peter C K Leung , Jung-Chien Cheng Tags Invasion , MMP-9 , NPFFR2 , Neuropeptide FF , Ovarian cancer

expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma cells Previous studies have indicated that GPR50 could protect against breast cancer development and decrease was analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell 7919, and the results showed that GPR50 was significantly up-regulated in HCC patients and CBRH-7919 cell Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation

< GPCR News < GPCRs in Oncology and Immunology Short-chain fatty acids and cancer Published date December the microbiota, serve as crucial links between the diet, gut microbiota, metabolism, immunity, and cancer histone deacetylase (HDAC) activities, protein modifications, signaling pathways, and gene expression in cells within the tumor microenvironment, particularly in tumor and immune cells. , cell death , immune response , metabolism , proliferation , propionate , short chain fatty acid Source

Oncology and Immunology Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer adenocarcinoma (PDAC) remains an aggressive disease that is expected to become the second cause of cancer siRNA-mediated knockdown of YES1, and transfection of epitogue-tagged YAP mutants in PANC-1 and Mia PaCa-2 cancer cells, models of the aggressive squamous subtype of PDAC. and suppressed the growth of Mia PaCa-2 cells xenografted into the flank of nude mice.

Cancer Caroline Formstone Abstract "Breast cancer is the most common form of cancer amongst women. Recent studies identify CELSR1, a key PCP gene, as a novel biomarker for early-stage breast cancer. Notably, our pilot data from luminal-type breast cancer cell lines representative of breast carcinomas and/or cell-matrix adhesions to dictate breast tumour invasive mechanism (b) quantify CELSR1 isoform cancer."

lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health concern and represents the most common cause of cancer-related death worldwide. lung cancer (NSCLC) METHODS: We explored the expression and prognosis of GPR37 in NSCLC through TCGA We detected the expression of GPR37 in NSCLC tissues and cell lines. The study explored the influence of GPR37 on tumor cell proliferation.

G-protein signaling 2 (RGS2), a member of the R4 family of RGS proteins, is overexpressed in many solid breast cancers, and its levels in prostate cancer significantly correlate with the metastatic stage and poor Whole cell assays showed the top 10 ranking compounds, AJ-1-AJ-10, to inhibit RGS2-Gαq interactions. All 10 compounds inhibited the growth of several RGS2 expressing cancers in cell culture assays. In addition, AJ-3 inhibited the migration of LNCaP prostate cancer cells in wound healing assays.

< GPCR News < GPCRs in Oncology and Immunology Biochemical pharmacology of adenylyl cyclases in cancer Understanding the signaling pathways involved in cancer progression is essential for the discovery of The precise mechanisms by which ACs contribute to cancer cell proliferation and invasion are not well The expression patterns of ACs in numerous cancers are discussed. , G protein , GPCR , Hallmarks of Cancer , cAMP signaling .