Search Results
81 items found for "Brian K Shoichet"
- Decoding GPCR Function: The Role of Mutagenesis in Rational Drug Discovery
., Shoichet, B. K., & Jacobson, K. A. (2010). K., Bouvier, M., & Babu, M. M. (2023). L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A., & May, L. T. (2016).
- Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild trauma
Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury "Traumatic brain injury (TBI) is a leading cause of disability in the US.
- Nanobodies: New Dimensions in GPCR Signaling Research
K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013). D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P. ., & Palczewski, K. (2023).
- 📰 GPCR Weekly News, March 11 to 17, 2024
This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, in a High Fat Diet-induced Mouse Model of Obesity GPCRs in Neuroscience Xanthurenic acid: A role in brain
- 📰 GPCR Weekly News, May 13 to 19, 2024
CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling Jiankun Lyu, Brian Shoichet, Bryan Roth, et al. for their research on AlphaFold2 structures guide prospective ligand discovery
- 📰 GPCR Weekly News, April 8 to 14, 2024
Katharina Grotsch, Bryan L Roth, Valery V Fokin et al. for their research on Virtual Screening of a Frizzleds act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into G protein coupling specificity at
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Pharmaceuticals (Basel, Switzerland), 14(5), 439. https://doi.org/10.3390/ph14050439 Chen, K. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003). C., Götz, K., Sungkaworn, T., Lohse, M. J., & Calebiro, D. (2016). I., & O'Malley, K. L. (2017). A., Sriram, K., Wiley, S.
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
K., Selent, J., Hill, S. J., & Calebiro, D. (2023). M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K. C., von Zastrow, M., Inoue, A., & Kobilka, B. K. (2022). Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.
- Identification of GPCRs Modulating Flow-induced Signaling Pathways in Vascular Endothelial Cells
Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe
- From DNA day to GPCR genomics
K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. K., Hildebrand, P. W., & Skiniotis, G. (2023).
- Ode to GPCRs
won the prize for his discovery that dopamine is a neurotransmitter produced in the basal ganglia, a brain prize awarded for work relevant to GPCR-mediated signaling was the 2012 Nobel Prize in Chemistry to Brian Novak, K. Skepticism surrounds triple Nobel winners. Brian K.
- 📰 GPCR Weekly News, June 24 to 30, 2024
Bryan Roth and Brian Krumm for their study on Molecular glues as potential GPCR therapeutics Drs
- 📰 GPCR Weekly News, December 4 to 10, 2023
Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. Research Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+
- GPCR/endocytosis/ERK signaling/S2R is involved in the regulation of the internalization...
extracellular signal-regulated kinases 1/2 (ERK1/2) signaling, p38 signaling, mitochondrial respiration and Na+/K+
- VAMP2: a crucial player in the delivery of MOR to the synapse
essential for developing new treatments for these disorders and advancing our understanding of the brain K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.
- 📰 GPCR Weekly News, November 13 to 19, 2023
Brian Krumm and Bryan Roth studied CryoEM structures of adhesion in GPCR CD97, filling gaps.
- Lysophosphatidic Acid and Several Neurotransmitters Converge on Rho-Kinase 2 Signaling to Manage...
through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+
- Regulators of G-protein signaling: essential players in GPCR signaling
members of the RGS family are selective for certain GPCRs, as a proof RGS4 which is expressed in the brain Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.
- 📰 GPCR Weekly News, January 29 to February 4, 2024
Sudha K Shenoy et al. perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators Illuminating the brain-genetically
- 📰 GPCR Weekly News, October 16 to 22, 2023
Brian Arey, and Dr. J. Silvio Gutkind.
- Decoding β-Arrestins: from Structure to function
hydrogen-deuterium exchange (HDX) mass spectrometry for time-dependent conformational insights (Komolov, K. proteins, presenting an array of effectors that could be recruited to GPCR–β-arrestin complexes (Xiao, K
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+
- 📰 GPCR Weekly News, December 18 to 31, 2023
Franziska M Heydenreich, Michel Bouvier, Brian Kobilka, M Madan Babu, and their team's work on Molecular
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
BERKY consists of a membrane linker, a BRET donor, an ER/K α-helix linker, a BRET acceptor, and an active
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
full control of signaling activity through a small protein GPCR via library-based screening Dorgham, K. candidate hits from library-based screening so that they can be tested in cell-based assays Akondi, K. small proteins show full in vivo efficacy in a highly stringent model of HIV transmission Steinbach, K.
- Adhesion GPCR Consortium Newsletter - May 2024
Bandekar with help from Nathan Zaidman and Abhishek K. Singh
- Serotonin Receptor 5-HT2A Regulates TrkB Receptor Function in Heteroreceptor Complexes
accordance with our findings demonstrating the prevalence of 5-HT2A–TrkB heteroreceptor complexes in these brain especially the striatum, demonstrating that the balance between TrkB and 5-HT2A may shift in certain brain heterodimerization and suggest that the regulated expression of 5-HT2A and TrkB is a molecular mechanism for the brain-region-specific