agonists reveal recognition motifs for the MRGPRD GPCR Chunyu Wang ,  Yongfeng Liu ,  Marion Lanier ,   Brian K Shoichet ,  Esther Martinborough ,  Jonathan F Fay ,  Can Cao ,   Bryan L Roth , et al. adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed Jillian G Baker ,  Erica K

., Shoichet, B. K., & Jacobson, K. A. (2010). K., Bouvier, M., & Babu, M. M. (2023). L., Gregory, K. J., White, P. J., Sexton, P. M., Christopoulos, A., & May, L. T. (2016).

Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury "Traumatic brain injury (TBI) is a leading cause of disability in the US.

K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013). D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P. ., & Palczewski, K. (2023).

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka, in a High Fat Diet-induced Mouse Model of Obesity GPCRs in Neuroscience Xanthurenic acid: A role in brain

CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling Jiankun Lyu, Brian Shoichet, Bryan Roth, et al. for their research on AlphaFold2 structures guide prospective ligand discovery

Katharina Grotsch, Bryan L Roth, Valery V Fokin  et al. for their research on Virtual Screening of a Frizzleds act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into G protein coupling specificity at

Pharmaceuticals (Basel, Switzerland), 14(5), 439. https://doi.org/10.3390/ph14050439 Chen, K. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003). C., Götz, K., Sungkaworn, T., Lohse, M. J., & Calebiro, D. (2016). I., & O'Malley, K. L. (2017). A., Sriram, K., Wiley, S.

K., Selent, J., Hill, S. J., & Calebiro, D. (2023). M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K. C., von Zastrow, M., Inoue, A., & Kobilka, B. K. (2022). Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics.

K., Bouvier, M., & Babu, M. M. (2023). K., Hoppe, N., Huang, X. P., Macdonald, C. B., Mehrota, E., Grimes, P.

Brian Arey is doing. https://www.ecosystem.drgpcr.com/dr-gpcr-virtual-cafe/ #gpcr #drgpcr #virtualcafe

K., Strader, D. J., Benovic, J. L., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. K., Hildebrand, P. W., & Skiniotis, G. (2023).

Bryan Roth and Brian Krumm   for their study on Molecular glues as potential GPCR therapeutics Drs

won the prize for his discovery that dopamine is a neurotransmitter produced in the basal ganglia, a brain prize awarded for work relevant to GPCR-mediated signaling was the 2012 Nobel Prize in Chemistry to Brian Novak, K. Skepticism surrounds triple Nobel winners. Brian K.

Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. Research Transcriptome analysis of Schizothorax oconnori (Cypriniformes: Cyprinidae) oocytes: The role of K+

extracellular signal-regulated kinases 1/2 (ERK1/2) signaling, p38 signaling, mitochondrial respiration and Na+/K+

essential for developing new treatments for these disorders and advancing our understanding of the brain K ´ onigstorfer, M. Mozhayeva, Y. Sara, T.C. Südhof, and ¨ E.T. Kavalali. 2001.

Brian Krumm and Bryan Roth studied CryoEM structures of adhesion in GPCR CD97, filling gaps.

fantastic paper on Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor Bryan Roth  and Brian Krumm  for their excellent study on Molecular glues as potential GPCR therapeutics Sabrina

article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian

members of the RGS family are selective for certain GPCRs, as a proof RGS4 which is expressed in the brain Avrampou, K., et al., RGS4 Maintains Chronic Pain Symptoms in Rodent Models.

through G-protein-coupled receptors (GPCRs), fine-tune motoneuron (MN) IME by modulating background K+

Sudha K Shenoy et al. perspectives of GPCR-based genetically encoded fluorescent indicators for neuromodulators Illuminating the brain-genetically

Brian Arey, and Dr. J. Silvio Gutkind.

hydrogen-deuterium exchange (HDX) mass spectrometry for time-dependent conformational insights (Komolov, K. proteins, presenting an array of effectors that could be recruited to GPCR–β-arrestin complexes (Xiao, K

K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).

Cell death signaling in Anopheles gambiae initiated by Bacillus thuringiensis Cry4B toxin involves Na+/K+

Franziska M Heydenreich, Michel Bouvier, Brian Kobilka, M Madan Babu, and their team's work on Molecular