August 2022 "G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies , and transduce to heterotrimeric G-proteins to generate different degrees of physiological responses Previous studies revealed how ligands with different efficacies activate GPCRs. Analyses reveal similar overall complex architecture, with local conformational differences. ligands, with residue-specific functional differences.

Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine Interestingly, there were also significant differences in receptor degradation, with S339fs5 having a

However, the pharmacokinetic properties of DOI differed among sexes - brain and plasma concentrations Together, these results suggest strain-dependent and sex-related differences in the behavioral and pharmacokinetic

Authors Kirti V Sawant , Krishna Mohan Sepuru , Brigith Penaranda , Emily Lowry , Roberto P Garofalo

Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger

Schwartz, and worked closely with Dr Birgitte Holst studying structural and mechanistic properties of Quick Recap Yamina and Jacek discussed their experiences with name mispronunciations, cultural differences Summary Embracing Cultural Differences and Collaboration Yamina and Jacek shared their experiences with name mispronunciations and variations and discussed the importance of embracing cultural differences Yamina agreed, emphasizing the importance of mental preparation and embracing different social situations