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184 items found for "British Pharmacological Society"

  • Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger, was appointed...

    appointed President of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Coincidentally, on the same day, Prof Pfleger was announced as a Fellow of the British Pharmacological Society. "ASCEPT is the peak professional society devoted to advancing excellence in Clinical and Experimental “I am honoured to be appointed President of ASCEPT, and am particularly excited given the Society’s conference

  • Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...

    October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment The network pharmacology method was used to constructe the "herb-component-target" network, and elucidated

  • Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)

    This study demonstrated the pharmacological properties and functions of PxOctβ3 in P. xylostella, thus

  • Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology

    As Chief Matchmaker, I recently had the pleasure of speaking with Beth Fleck, Director of In Vitro Pharmacology Beth is also the hiring manager for their open Principal Scientist, In Vitro Pharmacology role posted Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery

  • Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...

    April 2022 Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders Addex Therapeutics "Tim Dyer is the Co-Founder and CEO of Addex Therapeutics, which is focusing on the pharmacology

  • Exploring pharmacological inhibition of G q/11 as an analgesic strategy

    August 2022 "Background and purpose: Misuse of opioids has greatly affected our society. The aim of this study was to test this hypothesis pharmacologically by using potent and selective Gq/

  • Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

    September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer "Quantitative systems pharmacology (QSP) modeling is

  • Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...

    October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and

  • 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024

    We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you Here’s the refreshed schedule: Principles of Pharmacology I October 3, 10, 17, 24 Principles of Pharmacology Don’t miss out on insightful resources like '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

  • 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!

    GPCR Enthusiasts , Get ready for an exciting learning experience with our newly updated Principles of Pharmacology New Course Dates: Principles of Pharmacology I :  October 3, 10, 17, 24 (four sessions) Principles of Pharmacology II :  October 31, November 7, 14, 21, December 5 (five sessions) Courses Highlights Act Fast: Don’t miss this incredible opportunity to immerse yourself in the  Principles of Pharmacology and ' Advanced Data Analysis for GPCR Pharmacology' ."

  • Combined docking and machine learning identify key molecular determinants of ligand pharmacological

    detailed structure‐activity relationship that identifies small changes to the ligands that invert their pharmacological

  • 🎄 Have Yourself a Merry Little GPCRmas! ❄ Dec 9 - 15, 2024

    Congratulations to Andrew Tobin for an incredible week filled with prestigious events, including receiving the British Pharmacological Society Vane Medal and switching on the Christmas lights at the University of Glasgow and TPD Structural Biology Platforms GPCR Events, Meetings, and Webinars December 10 - 12, 2024 | Pharmacology | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group

  • Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...

    August 2022 Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, We now summarize important pharmacological, molecular, and cellular studies relevant to D1-mediated β-arrestin-related

  • A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...

    August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology monitor the activation state of G protein-coupled receptors are a useful addition to the molecular pharmacology evaluating its compatibility with photopharmacological ligands that contain a light-sensitive azobenzene moiety

  • GPCR News Flash! Top Updates You Can't-Miss! + University CheatSheet is finally available! ❄ Dec 2 - 8, 2024

    ’s Highlights: Congratulations to our amazing Board Member JoAnn Trejo for being elected to the British Pharmacological Society Honorary Fellowship! | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Principal Scientist, Medicinal Chemistry PhD fellowship in GPCR mechanosensing Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group

  • Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors

    Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the Therefore, CAN1404 acts as a pharmacological chaperone and can rescue cell surface expression and function effects of genetic mutations on GPCR function and provide a proof of therapeutic principle for FSHR pharmacological

  • GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...

    GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors. In the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term GPCR activities associated with the regulation of protein expression patterns, cellular stress responses and DNA integrity management. The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control complex cellular activities implicates them as key controllers of the functional balance between health and disease. A greater understanding of this function of GPCRs is likely to significantly augment our ability to further employ these proteins in a multitude of diseases. Read full article

  • Naggie and Rajagopal Elected Members of American Society for Clinical Investigation

    members — Susanna Naggie, MD, and Sudarshan Rajagopal, MD, PhD — have been elected to the American Society Naggie and Rajagopal are two of 95 new members elected to the society for 2022.

  • 📰 GPCR Weekly News, May 8 to 14, 2023

    Proteins Professor Andrew Hopkins, Exscientia’s founder and CEO, was elected as a Fellow of the The Royal Society Financial Results and Recent Highlights OMass Therapeutics presented at the 23rd BioEquity Conference British Participants Diagnosed with WHIM Syndrome GPCR Events, Meetings, and Webinars ASPET 2023 - American Society for Pharmacology and Experimental Therapeutics (May 18 - 21, 2023). (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023).

  • 📰 GPCR Weekly News, July 3 to 9, 2023

    Graeme Milligan for receiving the Order of British Empire from King Charles III in recognition of his Graeme Milligan was awarded the Order of British Empire by King Charles III for services to Biochemical Postdoctoral Fellow, Caron Lab NEW Clinical Trial Associate Research Scientist/Senior Scientist I - Molecular Pharmacology President, Medical Affairs Associate Director / Director, Clinical Operations Professor in Cardiovascular Pharmacology

  • All Aboard the GPCR Express: Your Weekly Update is here! Oct 14-20, 2024

    Gunnar Schulte for his excellent work on International Union of Basic and Clinical Pharmacology CXV: Registrations end TOMORROW for Principles of Pharmacology II Don't let this opportunity slip away to Seize the chance to enhance your understanding and expertise in pharmacology under the guidance of the Modules: October 31st: The Eyes to See- The Importance of Pharmacologic Assays. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and

  • GPCR Buzz of the Week | Sep 23 - 29, 2024

    Thrilling beginning to Principles of Pharmacology I We are excited to announce the start of our Principles of Pharmacology I course! Don’t miss this opportunity to advance your knowledge and skills in pharmacology! Modules: October 31st : The Eyes to See- The Importance of Pharmacologic Assays. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and

  • 📰 GPCR Weekly News, July 1 to 7, 2024

    Gunnar Schulte for his study on the International Union of Basic and Clinical Pharmacology. Jianming Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Here’s a sneak peek at what you can expect: Principles of Pharmacology in Drug Discovery I - Techniques Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Scientist - Discovery

  • GPCR Weekly Whirlwind: Top Receptor Highlights from Sep 30 - Oct 6, 2024!

    I We are diving into the second class of our Principles of Pharmacology I course with enthusiasm and you missed out on enrolling in this one, worry not – a spot is reserved just for you in Principles of Pharmacology Seize this opportunity to enhance your expertise and proficiency in pharmacology! Modules: October 31st : The Eyes to See- The Importance of Pharmacologic Assays. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and

  • Discover the Hottest GPCR News of the Week: Oct 7-13, 2024!

    Don't miss out on this chance to elevate your knowledge and skills in pharmacology! Apply unique pharmacologic assays and unconventional ligands to unveil GPCR activities. Emerging Voices in GPCR Biology in Special Issue of Molecular Pharmacology GPCR Events, Meetings, and GPCR Jobs HIGHLIGHT Senior Scientist, GPCR Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group Postdoctoral Scholar – iPSC in cardiac and endothelial

  • Exploring the Breakthroughs in GPCR Research

    Course Schedule and Details Every Thursday at 10 am EST Principles of Pharmacology in Drug Discovery Candidate Molecules Dates: September 5th to 26th, 2024 Overview: This course delves into the essential pharmacologic Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Director GPCR Drug Discovery Biologist Post-Doctoral Scientist- Molecular Pharmacology (FDE) Join Dr.

  • GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024

    the latest GPCR research, including breakthrough studies, upcoming events, and our newly announced pharmacology pharmacologic activity measurement, mechanisms of action, and GPCR discovery strategies. Principles of Pharmacology II October 31, November 7, 14, 21, December 5 (five sessions) (we skipped The Principles of Pharmacology I & II BUNDLE is your golden ticket to mastering the field. Secure your spot today and elevate your pharmacology expertise!

  • 📰 GPCR Weekly News, January 30 to February 5, 2023

    Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor Publishes Whitepaper Highlighting the Importance and Challenges in Unlocking “Undruggable” GPCRs Endocrine Society (June 4 - 8, 2023). 2023 Molecular Pharmacology (GRS) Seminar GRC. (June 10 - 11, 2023). (June 11 - 16, 2023). 19th World Congress of Basic & Clinical Pharmacology 2023. PhD student at Department of Drug Design and Pharmacology Software / database development postdoc at

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