C-C motif chemokine ligand 17

397 items found for "C-C motif chemokine ligand 17"

Posts (279)

Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
August 2022 "Fluorescently labeled ligands are versatile molecular tools to study G protein-coupled receptors Here, we report the structure-based development of fluorescent ligands targeting the intracellular allosteric binding site (IABS) of the CC chemokine receptor 2 (CCR2), a class A GPCR that has been pursued as a By means of these studies, we developed 14 as a fluorescent CCR2 ligand, enabling cell-free as well Thus, our small-molecule-based fluorescent CCR2 ligand 14 represents a promising tool for future studies
Canonical chemokine receptors as scavenging “decoys”
In all these situations, chemokines interact with seven-transmembrane chemokine-type G protein-coupled (CKRs) that signal via Gαi and 4 official atypical chemokine receptors (ACKRs) which engage in ligand sites, while maintaining the responsiveness of canonical G protein-coupled CKRs that bind to the same ligand ligands and ultimately affect cell migration (Cardona, A. CKRs should be considered when evaluating the safety and therapeutic efficacy of blocking receptor-ligand
Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembra
Specifically controlling the activity of GPCR dimers with ligands is a good approach to clarify their

Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
dermatitis , BAM8-22 , BP , Beta chain , Bovine adrenal medulla peptide 8-22 , Bullous pemphigoid , C-C motif chemokine ligand 17 , CCL17 , CGRP , CIU , COPD , CRSsNP , CRSwNP , CSF2 , CSU , Calcitonin gene-related
Chemokine Physiology in Cancer
Chemokines are a physiologic system that is finely tuned by ligand and receptor expression, ligand or In this article we review current literature on the diversity of chemokine ligands and their cellular receptors that detect and process chemotactic gradients and illustrate how differences between ligand Facets of chemokine physiology across discrete cancer immune phenotypes are contrasted to existing chemokine-centered GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled This protein ligand plays an important role in obesity and inflammatory processes. Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g This may help to develop more potent ligands for the treatment of inflammatory related diseases." GPCR News and get weekly notifications about the GPCR field Share < Previous Next >