Latrophilin-1 drives neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans function Latrophilins are highly conserved Adhesion GPCRs playing essential roles However, there is evidence that Latrophilins in the nematode Caenorhabditis elegans can also function independently of their seven-transmembrane domain and C terminus (trans function). elegans nervous system.

In this study, we investigated the role of chemical signaling in axon regeneration in Caenorhabditis elegans SIGNIFICANCE STATEMENT In C. elegans , axon regeneration is positively regulated by the EGL-30 Gqα-JNK C. elegans secretes a family of small-molecule pheromones called ascarosides, which serve various functions

subunits required for the control of response to polystyrene nanoparticles in the range of μg/L in C. elegans The aim of this study was to identify Gα proteins mediating function of neuronal G protein-coupled Caenorhabditis elegans was used as an animal model, and both gene expression and functional analysis

A. flagrans develops adhesive traps and recognizes its prey, Caenorhabditis elegans, through nematode-specific The C. elegans ascaroside-sensing GPCR, SRBC66 and GPCRs of many fungi are also predicted for dual localization An SRBC64/66-GprC chimaeric protein was functional in A. flagrans, and C. elegans SRBC64/66 and DAF38 Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

current dogma is that chemoattractants G protein-coupled receptors (GPCRs) activate β phospholipase C (PLCβ) while receptor tyrosine kinases (RTKs) activate γ phospholipase C (PLCγ). chemoattractant/GPCR-mediated membrane recruitment of PLCγ2 constitutes GPCR-mediated phospholipase C receptor (GPCR) , calcium-promoted Ras inactivator (CAPRI) , chemotaxis , neutrophils , phospholipase C (PLC) , g2 phospholipase C (PLCγ2) .