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C5a is established to interact with a set of genomically related transmembrane receptors, like C5aR1 The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that Currently, the exact function of the C5aR2 is actively debated in the context of C5aR1, even though both C5aR1 and C5aR2 are coexpressed on myriads of tissues. The functional relevance of C5aR2 appears to be context-dependent compared to the C5aR1, which has received

Complement factor C5a exerts its effect through the activation of C5aR1, chemotactic receptor 1, and Orthosteric and allosteric antagonists of C5aR1 are a novel strategy for anti-inflammatory therapies. Here, we discuss recent crystal structures of inactive C5aR1 in terms of an inverted orientation of helix An analysis of mutual interactions of subunits in the C5aR1-G protein complex has provided new insights By comparing two C5aR receptors C5aR1 and C5aR2 we explained differences between their signaling pathways

recognition and G protein subtype selectivity of kisspeptin receptor Structural analysis of the human C5a-C5aR1 complex using cryo-electron microscopy Structural analysis of the human C5a-C5aR1 complex using cryo-electron

In this work, we analyze interactions in the allosteric sites of the PAR2, C5aR1, and GCGR receptors

relapse GPCRs in Oncology and Immunology The GPCR adaptor protein Norbin controls the trafficking of C5aR1

signaling induced by a chemerin-derived agonist Functional profiling of the G protein-coupled receptor C3aR1

Structural and Molecular Insights into GPCR Function Ternary model structural complex of C5a, C5aR2,