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< GPCR News < GPCRs in Oncology and Immunology C5aR2 receptor: The genomic twin of the flamboyant C5aR1 The C5aR1 is a classical G-protein-coupled receptor (GPCR), whereas C5aR2 is a nonclassical GPCR that Currently, the exact function of the C5aR2 is actively debated in the context of C5aR1, even though both C5aR1 and C5aR2 are coexpressed on myriads of tissues. The functional relevance of C5aR2 appears to be context-dependent compared to the C5aR1, which has received

News < GPCRs in Oncology and Immunology The GPCR adaptor protein Norbin controls the trafficking of C5aR1 We recently showed that Norbin is expressed in neutrophils, limits the surface levels of the GPCRs C5aR1 We show that Norbin mediates the agonist-induced internalisation of C5aR1 through a β-arrestin-dependent mechanism and limits the recycling of internalised C5aR1 and CXCR4 back to the cell surface. Our study demonstrates how Norbin suppresses C5aR1 and CXCR4 function in neutrophils and increases our