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44 items found for "CCR1"

Posts (35)

  • Feeder or trigger – CCR2 as a scavenger and regulator of cell migration

    CCR2 vs CCR1 scavenging signatures CCR1 is constitutively phosphorylated, constitutively interacts with In line, β-Arrestin KO cells showed a major reduction in CCL14 scavenging by CCR1, in contrast with a on CCR1, in contrast with CCR2, indicating that β-arrestin regulates scavenging and signaling of CCR1 to a greater extent than CCR2. In monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2, and CCR5 switch

  • Canonical chemokine receptors as scavenging “decoys”

    CCR2, CXCR2, CXCR3, and CX3CR1) (Cardona, A. E., et al. 2008). other chemokine scavenger receptors that where shown to couple to GRKs, β-arrestins, or both such as CCR1 CCR1 is constitutively phosphorylated, constitutively interacts with β-arrestin2, and constitutively Interestingly, in monocytes and dendritic cells exposed to treatments mimicking inflammation, CCR1, CCR2 , and CCR5 switch purely to scavenging (D'Amico G. et al. 2000), becoming incapable of promoting cell

  • Chemokine receptor-targeted drug discovery: progress and challenges

    The anti-CCR4 antibody mogamulizumab has also been approved in Japan and by the FDA for the treatment , CCR5, CCR6, CCR7, and CXCR3) and so inhibition of this process through blockade of a single receptor An example is CCL5 which binds to CCR1, CCR3 and CCR5, and induces different patterns of receptor recycling where CCR5 recycles back to the cell surface (Mack et al. 1998), CCR3 is partially restored to the cell surface and partially targeted to lysosomes (Zimmermann, Conkright, and Rothenberg 1999) and CCR1 does

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