Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1

< GPCR News < GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies When CCR6 binds to its sole ligand CCL20, a signaling network is produced. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Design: We analyzed the effects of one GPCR coexpressed with CCR5, EBI2, on HIV-1 replicative cycle. Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Results: We showed that EBI2 is naturally expressed in primary CD4+CCR5+ T cells, and that CCR5 and EBI2 Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

< GPCR News < GPCRs in Oncology and Immunology CCR7 acts as both a sensor and a sink for CCL19 to coordinate , we demonstrate that in addition to its role as the sensory receptor that steers migration, CCR7 also Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and We show that CCR7 internalization also acts as an effective sink for the chemoattractant, dynamically Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel

the lysophosphatidic acid-CCN axis in signal transduction Published date September 1, 2023 Abstract "CCN1 Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation activate GPCR-mediated intracellular signaling to induce the production of extracellular modulators (CCN1

containing eight GPCR-related genes (atypical chemokine receptor 3 (ACKR3), C-C chemokine receptor type 3 (CCR3 ), CCR7, frizzled homolog 5 (FZD5), metabotropic glutamate receptor 8 (GRM8), hydroxycarboxylic acid