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9 items found for "CCR1"

  • Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5

    Immunology Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors CCR1 and CCR5. These 3 to 10-residue peptides displayed weak potency but, surprisingly, retained their signaling on CCR1 In conclusion, chemokine N-termini can be mimicked to produce small CCR1-selective agonists, as well

  • GPCR signaling contributes to immune characteristics of microenvironment and process of EBV-induced lymphomagenesis

    Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1

  • CCL5-producing migratory dendritic cells guide CCR5+ monocytes into the draining lymph nodes

    < GPCR News < GPCRs in Oncology and Immunology CCL5-producing migratory dendritic cells guide CCR5+ monocytes Migratory cDCs, however, upregulated Ccr7, Ccl17, Ccl22, and Ccl5. Migratory monocytes expressed Ccr5, a high-affinity receptor for Ccl5. Antigen exposure in mixed-chimeric Ccl5-, Ccr2-, Ccr5-, Ccr7-, and Batf3-deficient mice demonstrated that while antigen-bearing DCs use CCR7 to reach the LN, monocytes use CCR5 to follow CCL5-secreting

  • Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides)

    Oncology and Immunology Characterization, expressional and evolutionary analysis of five fish-specific CCRs (CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides) Published In this study, five fish-specific CCRs, namely CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b, were identified Selection pressure analysis revealed that CCR4La, CCR4Lc, CCR12a1, and CCR12a2 underwent negative selection pressure, whereas CCR12b experienced positive selection pressure.

  • CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases

    < GPCR News < GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies When CCR6 binds to its sole ligand CCL20, a signaling network is produced. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

  • The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells and boosts HIV-1 R5 replication

    < GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Design: We analyzed the effects of one GPCR coexpressed with CCR5, EBI2, on HIV-1 replicative cycle. Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Results: We showed that EBI2 is naturally expressed in primary CD4+CCR5+ T cells, and that CCR5 and EBI2 Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

  • CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration

    < GPCR News < GPCRs in Oncology and Immunology CCR7 acts as both a sensor and a sink for CCL19 to coordinate , we demonstrate that in addition to its role as the sensory receptor that steers migration, CCR7 also Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and We show that CCR7 internalization also acts as an effective sink for the chemoattractant, dynamically Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel

  • From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction

    the lysophosphatidic acid-CCN axis in signal transduction Published date September 1, 2023 Abstract "CCN1 Our group previously reported that LPA induces production of CCN1 protein in human prostate cancer cell The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small In some model systems, CCN1 and CCN2 play key roles in LPA/S1P-induced cell migration and proliferation activate GPCR-mediated intracellular signaling to induce the production of extracellular modulators (CCN1

  • Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis

    containing eight GPCR-related genes (atypical chemokine receptor 3 (ACKR3), C-C chemokine receptor type 3 (CCR3 ), CCR7, frizzled homolog 5 (FZD5), metabotropic glutamate receptor 8 (GRM8), hydroxycarboxylic acid

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