Oncology and Immunology Characterization, expressional and evolutionary analysis of five fish-specific CCRs date October 24, 2024 Abstract "CC chemokine receptors (CCRs), the numbers of the G protein-coupled receptor In this study, five fish-specific CCRs, namely CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b, were identified The correction of nomenclatures of these CCRs were confirmed by phylogenetic analysis, structural analysis The potential ligands for these five CCRs were identified by molecular docking analysis, with finding

< GPCR News < GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies When CCR6 binds to its sole ligand CCL20, a signaling network is produced. The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. To date, there are no drugs against CCR6 approved, and the development of small molecules against CCR6 Tags CCR6 , GPCRs , Th17 cells , antibody , immune system , inflammation , therapy .

< GPCR News < GPCRs in Oncology and Immunology CCL5-producing migratory dendritic cells guide CCR5+ monocytes Migratory cDCs, however, upregulated Ccr7, Ccl17, Ccl22, and Ccl5. Migratory monocytes expressed Ccr5, a high-affinity receptor for Ccl5. Antigen exposure in mixed-chimeric Ccl5-, Ccr2-, Ccr5-, Ccr7-, and Batf3-deficient mice demonstrated that while antigen-bearing DCs use CCR7 to reach the LN, monocytes use CCR5 to follow CCL5-secreting

< GPCR News < GPCRs in Oncology and Immunology The EBI2 receptor is coexpressed with CCR5 in CD4+ T cells Design: We analyzed the effects of one GPCR coexpressed with CCR5, EBI2, on HIV-1 replicative cycle. Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR. Results: We showed that EBI2 is naturally expressed in primary CD4+CCR5+ T cells, and that CCR5 and EBI2 Conclusions: EBI2 expression in CD4+CCR5+ cells boosts HIV-1 R5 productive infection.

< GPCR News < GPCRs in Oncology and Immunology CCR7 acts as both a sensor and a sink for CCL19 to coordinate , we demonstrate that in addition to its role as the sensory receptor that steers migration, CCR7 also Upon exposure to the CCR7 ligand CCL19, dendritic cells (DCs) effectively internalize the receptor and We show that CCR7 internalization also acts as an effective sink for the chemoattractant, dynamically Such a dual role of CCR7 as a GPCR that both senses and consumes its ligand can thus provide a novel

Immunology Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines are often elevated in disease and CCR5. modulator boosting the signal of several chemokine variants on CCR5. as CCR5-selective modulators."

Enhanced expression of chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated Therapeutic targeting CCR1 showed promising efficacy with EBV eradication, T-cell activation, and lymphoma Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1

containing eight GPCR-related genes (atypical chemokine receptor 3 (ACKR3), C-C chemokine receptor type 3 (CCR3 ), CCR7, frizzled homolog 5 (FZD5), metabotropic glutamate receptor 8 (GRM8), hydroxycarboxylic acid