synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling regulates cellular metabolism afferent and peripheral efferent signals that link specific neural cell populations to the regulation of metabolic Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic Variants identified in PKA subunit genes cause Cushing syndrome that is characterized by metabolic dysregulation

October 2022 "The prefrontal cortex (PFC) is a hub for cognitive control, and dopamine profoundly influences its functions. In other brain regions, astrocytes sense diverse neurotransmitters and neuromodulators and, in turn, orchestrate regulation of neuroactive substances. However, basic physiology of PFC astrocytes, including which neuromodulatory signals they respond to and how they contribute to PFC function, is unclear. Here, we characterize divergent signaling signatures in mouse astrocytes of the PFC and primary sensory cortex, which show differential responsiveness to locomotion. We find that PFC astrocytes express receptors for dopamine but are unresponsive through the Gs/Gi-cAMP pathway. Instead, fast calcium signals in PFC astrocytes are time locked to dopamine release and are mediated by α1-adrenergic receptors both ex vivo and in vivo. Further, we describe dopamine-triggered regulation of extracellular ATP at PFC astrocyte territories. Thus, we identify astrocytes as active players in dopaminergic signaling in the PFC, contributing to PFC function though neuromodulator receptor crosstalk." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria. The physiological activities of UCPs have been hotly contested, and the involvement of UCPs in the pathogenesis and progression of diabetes mellitus is among the greatest concerns. UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production, potentially protecting diabetes mellitus patients who are experiencing oxidative stress. Objectives: The objectives of the study are to find out the newest ways to treat diabetes mellitus through protein uncoupling." Read more at the source #DrGPCR #GPCR #IndustryNews

March 2022 Inversago Pharma Announces Dosing of First Participant with Metabolic Syndrome in Phase 1B unique portfolio of CB1 inverse agonists, announced today the dosing of the first participant with metabolic pharmacokinetics and safety profile of Inversago’s lead molecule, INV-202, on a targeted population with metabolic

October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation G-protein coupled receptors (GPCRs), their inhibitory regulators and downstream enzymes catalyzing glycogen metabolism

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose and lipid metabolism -1R) is not required for enteroendocrine L cell GLP-1 secretion and glucose homeostasis nor for the metabolic

expressed by SKM at relatively high levels (β2-adrenergic receptor and CRF2 receptor) and studied the acute metabolic The acute metabolic effects following agonist activation of β2-adrenergic and, potentially, CRF2 receptors The acute metabolic effects of UCN2 were not mediated by SKM Gs signaling.

However, our knowledge of how GPCRs regulate liver metabolism and fibrosis in the different cell types

September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

Experimental studies proposed a direct effect of follicle-stimulating hormone (FSH) on the skeletal metabolism

GPCR Activation and Signaling GPCR screening reveals that the metabolite receptor HCAR3 regulates epithelial and Free Energy Perturbation A computational insight on the aromatic amino acids conjugation with [Cp American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic

and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment High Metabolite Diversity, and Biological Activity Advances in steroid research from the pioneering neurosteroid concept to metabolomics American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic Schmeizl NEW Scientist NEW Lead Researcher NEW Post-Doctoral Fellow Sr Scientist in Obesity, Muscle, and Metabolism

in various physiological functions, such as sensory perception, reproduction, development, growth, metabolism , and are also linked to major diseases, such as neuroinflammatory, metabolic and autoimmune diseases Some studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders IM (3,3′‐methylenebis‐1H‐indole) has been identified as a positive allosteric modulator of GPR84, a metabolite

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join us at the Endocrine Metabolic GPCRs event on April in Cardiology, Endocrinology, and Taste Propionate functions as a feeding-state-dependent regulatory metabolite

Phase 1 results and supportive preclinical package assist in the launch of Phase 2 clinical development Metabolic successful completion of the Phase 1 Clinical Trial for its INV-202 molecule that focuses on treating metabolic

Understanding the mechanism by which MRAP2 regulates G protein-coupled receptors helps in elucidating the metabolic pathways involved in metabolic dysfunction and in developing new drugs as specific targets of the MRAP2

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. Reaction Orphan GPR52 as an emerging neurotherapeutic target Sustained antidepressant effects of ketamine metabolite

is true for the glucagon receptor (GCGR), which mediates physiological regulation of hepatic glucose metabolism Together, these results implicate the endosomal signaling paradigm in metabolic regulation by glucagon

GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs Muscle Cell Movement Hepatic extracellular ATP/adenosine dynamics in zebrafish models of alcoholic and metabolic

One successful strategy is the so-called metabolic surgery whose beneficial effects are beyond dietary , a logical and rational approach is the use of the dual and triagonism of GCPC to achieve complete metabolic

GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs biarylamine acting as agonist at human β3 adrenoceptors and exerting BRL37344-like effects on mouse metabolism Adults Confo Therapeutics Secures VLAIO Grant Supporting Drug Discovery & Development In Endocrine And Metabolic

GPCR Partnered Events April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join the Endocrine Metabolic GPCRs in GPCR Research Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join our Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. alters G-protein coupled receptor-mediated vasocontraction in rat coronary arteries GPCRs involved in metabolic

Classified GPCR News from September 16th to 22nd, 2024 Industry News Inversago Pharma’s INV-347 improves metabolic Progress In Biology And Drug Discovery GLP-1/FGF21 dual agonist ZT-003 shows promising results for metabolic Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism

First metabolic profiling of 4-n-nonylphenol in human liver microsomes by integrated approaches to testing and assessment: Metabolites, pathways, and biological effects.

in GPCR Research High-throughput G protein-coupled receptor-based autocrine screening for secondary metabolite Reviews, GPCRs, and more Class B1 GPCRs: Insights into Multi-Receptor Pharmacology for the Treatment of Metabolic

) exhibits a series of cell-activating properties, such as promoting cell spreading, migration, and metabolic reduced the uptake, which was accompanied by the nullification of the promoting effect of F-Hst1 on cell metabolic

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. pathophysiology Common changes in rat cortical gene expression after antidepressant drug treatment: impacts on metabolism