DEGs in the hypothalamus (hub genes: Nod2, Serpine1, Cebpb, Nfkbil1, Ripk2, Zfp36, Traf6, Akap8, Gfer, Cxcl10

< GPCR News < GPCRs in Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced CXC chemokine receptor 4 (CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers , and β-arrestin recruitment, while CXCL12 binding to CXCR4 remained unaffected. The addition of lysophosphatidic acid (LPA) further hindered CXCL12-induced Gαi/o recruitment to CXCR4 LPA or alkyl-OMPT inhibited CXCL12-induced migration in various cancer cells that endogenously express

The team’s projects are devoted to the activation/function of CXCR4-ACKR3 (CXCR7) receptors of the CXCL12 functions of chemokines and their receptors, for which she made important breakthroughs regarding the CXCL12 In particular, FB contributed to the discovery that CXCL12 is the ligand for the CXCR4 receptor and can FB’ team has identified the orphan CXCR7/ACKR3 receptor as being the 2nd receptor for CXCL12, which behaves as a modulator of CXCL12/CXCR4 functions.

< GPCR News < GPCRs in Oncology and Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil Here, we characterized the role for heterodimer and show that the Cxcl1-Cxcl2 heterodimer is a potent shown that the heterodimer binds glycosaminoglycans with higher affinity and more efficiently than Cxcl1

understand the signaling pathways and activation mechanisms of the Dopamine D3 receptor and the CXCR4-CXCL12