Search Results
73 items found for "Cam Sinh Lu"
- 📰 GPCR Weekly News, May 20 to 26, 2024
This week's highlight includes congrats to: Cam Sinh Lu, for his first Dr.
- Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based kinet
August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling We found that preincubation and luminescence reading at room temperature were optimal as compared to
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
factors, including ETS, c-Jun, and Fos, modulating gene expression and influencing cellular functions (Lu Lu, N., & Malemud, C. J. (2019). S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).
- 📰 GPCR Weekly News
The Ca2+/CaM, Src kinase and/or PI3K-dependent EGFR transactivation via 5-HT2A and 5-HT1B receptor subtypes
- 📰 GPCR Weekly News, August 21 to 27, 2023
Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology' Yao Lu
- Adhesion GPCR Consortium Newsletter - May 2024
Another chapter was being written for me and has been in full redaction since then. Mariachi song: I typically do not sing to these since they are dear to Mexican childhood memories, and Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs while executing your best perreo or Luis Enrique’s “Yo no sé mañana” while a stranger takes you floating Singh
- 📰 GPCR Weekly News, July 1 to 7, 2024
Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Yao Lu
- Structural landscape of the Chemokine Receptor system
TM7 and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu constitutively active receptors, meaning they can signal independently of agonist (Casarosa, Bakker et al. 2001, Luker recycling of chemokines without activating G-protein pathways (Randolph-Habecker, Rahill et al. 2002, Luker
- Third Rock pushes newest fund over $1B line as it marks 15 years in venture capital
Since then, Celniker has helped usher in an additional fund and headed a few startups as interim CEO. Adding it all up, Third Rock has raised $3.8 billion since its inception.
- Comparative studies of AlphaFold, RoseTTAFold and Modeller: a case study involving the use of...
G-protein-coupled receptor (GPCR) proteins are particularly interesting since they are involved in numerous modeling RMSD of 2.17 Å, which is better than AlphaFold's 5.53 Å and RoseTTAFold's 6.28 Å, probably since
- Diversification of PAR signaling through receptor crosstalk
signalling pathways triggered, to the physiological and pathological relevance of these interactions, since
- Michel Bouvier appointed Knight of the Ordre national du Québec
It has been awarded annually since 1985 to distinguished individuals who have strived, in an exceptional
- From DNA day to GPCR genomics
Since then, the National Human Genome Research Institute (NHGRI) has supported annual events across the C., Lundin, L. G., & Schiöth, H. B. (2003).
- 📰 GPCR Weekly News, August 28 to September 3, 2023
Transforming Growth Factor β-Mediated Antifibrotic G Protein-Coupled Receptor Landscape Tampering in Lung ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling CCR7 acts as both a sensor and a sink
- 📰 GPCR Weekly News, April 1 to 7, 2024
This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Minh and the team are looking for collaborators from academia and industry.
- Exscientia and Sanofi Establish Strategic Research Collaboration to Develop AI-driven Pipeline ...
The companies have been working together since 2016 and in 2019, Sanofi in-licensed Exscientia ’s novel
- GPCRs are not simple on-off switches: deep dive into GPCR-ligand interactions
However, GPCRs are not simple on-off switches (Rosenbaum, Rasmussen, and Kobilka 2009), since they are 1984 (Cerione et al. 1984), where reconstitution of purified β2-adrenergic receptors from guinea pig lung
- Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger, was appointed...
Prof Pfleger has served on the ASCEPT Board since 2016 and was Chair of the Scientific Advisory Committee
- TeachOpenCADD - A teaching platform for computer-aided drug design
Since we cover both the theoretical as well as practical aspect of these topics, the platform addresses
- Pharmacophore-guided Virtual Screening to Identify New β 3 -adrenergic Receptor Agonists
Ligand-based pharmacophore modeling was performed since no 3D structure of human β3 -AR is yet available
- G protein-coupled receptors that influence lifespan of human and animal models
protein-coupled receptors (GPCRs) may be a good option to try to prolong our life while maintaining good health since
- Anosmin 1 N-terminal domains modulate prokineticin receptor 2 activation by prokineticin 2
In the current report we present evidence of the modulation of PK2/PKR2 activity by anosmin 1, since
- Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein kinase C...
Moreover, since pharmacological tools to study PKC isozymes generally lack specificity and/or potency
- In Vitro and In Silico Characterization of Kurarinone as a Dopamine D 1A Receptor Antagonist and ...
Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition
- Lack of Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin...
However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic
- Glyco-sulfo hotspots in the chemokine receptor system
interactions between the negative sulfate groups in the N-terminus and the positively charged chemokines (Ludeman removal are ruled out it is possible that indirect effects may also contribute to the observed phenotype since
- Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered
., Sinha, S., Silas, A. J., Ghassemian, M., Kufareva, I., & Ghosh, P. (2024).
- 📰 GPCR Weekly News, September 11 to 17, 2023
Since you are reading this newsletter, you only have to click on the event page to join us.