Search Results
36 items found for "Charles R Mackay"
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein
- Ep 96 with R. Scott Struthers
GPCR Podcast << Back to podcast list Scott Struthers R. R. Scott Struthers on the web LinkedIn Google Scholar Crinetics Radionetics Dr.
- GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment
Authors Charles H Williams , Leif R Neitzel , Jessica Cornell , Samantha Rea , Ian Mills , Maya S Silver , Jovanni D Ahmad , Konstantin G Birukov , Anna Birukova , Henry Brem , Betty Tyler , Eli E Bar , Charles
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
with decitabine (DAC) demonstrated initial safety and efficacy in patients with relapsed/refractory (R/ R) AML. The current study aimed to identify molecular predictors of response to ONV + DAC in R/R AML patients A total of 44 R/R AML patients were treated with ONV + DAC and considered evaluable for efficacy. PLK1 inhibition with ONV in combination with DAC could be a potential therapy in R/R AML patients, particularly
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
bifunctional GLI transcription factors generate both GLI-activators (GLI-A) and GLI-repressors (GLI-R) The formation of GLI-A/GLI-R requires cilia. , and the ankyrin repeat protein ANKMY2 that direct cAMP/protein kinase-A signaling by cilia in GLI-R GLI-A formation only, or dual regulation of either lack of GLI-R or excess GLI-A formation. complex tissue-specific GLI-effector requirements in morphogenesis and point to tissue-specific GLI-R
- Ep 104 with Dr. Raul Gainetdinov
Raul Gainetdinov Raul R. Before SPBU, Raul R. In 2018-2020, Raul R.
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
in Axons Joseph Duman Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Kimberley Tolias Lab Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Mihaylov Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Flynn, Helen R.2, Sampedro-Castaneda Institute, UK 2Proteomics Science Technology Platform, The Francis Crick Institute, UK" About Simeon R. have recently also developed a strong interest in adhesion GPCRs and in particular, Bai1. " Simeon R.
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
autoantibodies were related inversely to markers of left ventricular fibrosis indicated by T1 mapping (r = -0.362, P < 0.05) and global longitudinal strain (r = -0.323, P < 0.05). myocardial mitochondrial coupling as measured by high-resolution respirometry in myocardial biopsies (r In insulin-resistant HF patients, AT2R autoantibodies were decreased (r = -.240, P < 0.05), and AT1R autoantibodies were increased (r = 0.212, P < 0.05).
- LP2, a cyclic angiotensin-(1-7) analog extended with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice
Prior to efficacy studies, immunohistochemistry on an untreated tissue array demonstrated that the AT 2 R Kinome analyses and validation of elected kinase inhibition indicated that LP2-mediated AT 2 R stimulation inhibitory potential of colorectal cancer. " Authors P Namsolleck , L de Vries , G N Moll Tags AT(2)R
- Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India
Authors R Mishra, S K Biswas, S Nandi, S Mahajan, K G Sai Balaji, V Gairola, D Poloju, S Gulzar, K P Singh, R K Singh, G K Sharma Tags Genome sequence , Lumpy skin disease , Molecular diversity , Virulence
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
ARB1 and ARB2 correlated negatively CERAD Trail Marking A and B (R ≤ -0.26, p ≤ 0.043), while CHRM3 correlated positively with Chadler Fatigue Scale (R = 0.37, p = 0.0087).
- Ep 105 with Annabelle Milner
As part of the degree, she undertook a 1-year research-based placement at the Charles Perkins Centre
- Ep 57 with Dr. Peter Robert Banks
These roles included management of PerkinElmer’s BioPharma R&D program and Chair of the company’s Scientific
- Ep 13 with Dr. Amynah Pradhan
Andrew Charles that who specialized in animal models of migraine and delta-opioid receptors as a therapeutic
- Ep 58 with Dr. Juan José Fung
discovery company focused on targeting GPCR heteromers in cancer, headquartered in Seoul, Korea, with an R&
- A journey from Duke to McGill along the dopamine circuit
Francisco, he joined the CNRS as a Research Fellow in 1987 in the INSERM Laboratory directed by Jean-Charles
- TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling
C terminal amino acids, and that TIPE2 protein interacted with PIP2 and PIP3 through its positively charged Authors Jiyeon Yu , Ali Zamani , Jason R Goldsmith , Zienab Etwebi , Chin Nien Lee , Youhai H Chen ,
- Ep 17 with Dr. Yamina Berchiche
Yamina Berchiche on the web D r.
- Ep 136 with Murat Tunaboylu & Ben Holland
Following this, he joined an early-stage medical device start-up and in 5 years was responsible for project R&
- Ep 84 with Rosie Dawaliby
I have 10 years of experience in the development and management of R&D projects and teams in the field
- Ep 106 with Dr. Bruno Giros
Francisco, he joined the CNRS as a Research Fellow in 1987 in the INSERM Laboratory directed by Jean-Charles
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
distributions among five states that lie along the activation pathway of adenosine A 2A receptor (A 2A R)
- Ep 95 with Chris Langmead
He also directs a collaborative neuroscience R&D program with Servier (France) and is the co-founder
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
Habgood , Amanda L Tatler , Katalin Susztak , Matthew Palmer , Stefan Offermanns , Neil C Henderson , R
- DANGER Signals Activate G-Protein Receptor Kinases Suppressing Neutrophil Function and Predisposing to Infection After Tissue Trauma
, David Gallo , Sidharth Shankar , Barbora Konecna , Yohan Han , Valerie Banner-Goodspeed , Krystal R Capers , Seong-Gyu Ko , Leo E Otterbein , Kiyoshi Itagaki , Carl J Hauser.
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
. 1.09 ± 0.42, p < 0.001) and showed a positive correlation with immunostaining of protein in OSCC (r
- Stable Binding of Full-Length Chemerin is Driven by Negative Charges in the CMKLR1 N-terminus
News < GPCRs in Oncology and Immunology Stable Binding of Full-Length Chemerin is Driven by Negative Charges