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Get ready to stay up-to-date with the latest research, advancements, and news in the field. From the scientist’s view: a conversation with … Chris Tate AI is dreaming up drugs that no one has ever

☕ We are excited to announce our rescheduled Dr. GPCR Virtual Cafe session with Dr. Matthew E. on Friday, October 7th at 1 PM ET. Don't miss the chance to listen to his latest research on the field. It's a great opportunity to get warmed up for the upcoming Summit starting the next Monday. Get your ticket today on Eventbrite! ➡https://bit.ly/3CmntVn

September 2022 "Perception of threats is essential for survival. Previous findings suggest that parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain areas, such as the midbrain and hypothalamus, for immediate avoidance. Yet little is known about whether and how multi-sensory innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain area for threat perception and learning. Here, we report that neurons expressing calcitonin gene-related peptide (CGRP) in the parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem respond to multi-sensory threat cues from various sensory modalities and relay negative valence to the lateral and central amygdala, respectively. Both CGRP populations and their amygdala projections are required for multi-sensory threat perception and aversive memory formation. The identification of unified innate threat pathways may provide insights into developing therapeutic candidates for innate fear-related disorders." Read more at the source #DrGPCR #GPCR #IndustryNews

We've refreshed the schedule and can’t wait for you to join us on these new dates. New Course Dates: Principles of Pharmacology I :  October 3, 10, 17, 24 (four sessions) Principles Grab this chance to deepen your understanding of pharmacology and take your knowledge to the next level Take advantage of a 25% early bird discount for premium members! GPCR Event Spotlight    11th Adhesion GPCR Workshop    Location:  Mexico City Dates:  October 23-25,

February 2022 "InterAx Biotech AG and Boehringer Ingelheim take first steps towards collaborating to

Nanobody binding stabilizes G-protein-coupled receptors (GPCR) in a fully active state and modulates intracellular binding partner is bound, in which case the receptor is only stabilized in an intermediate-active state

analyzes their significance in GPCR internalization dynamics, internalization routes, postinternalization fates

Our previous Markov State Model (MSM) analysis of molecular dynamics simulations of membrane-embedded

The conformational landscapes analyzed by Markov state models revealed that the overall conformation

generation • Mid-term global expansion plans include drug discovery technology investments, licensing late-stage Chris Cargill appointed as President and Chief Executive Officer • Dr.

simulations of G protein-coupled receptor-ligand complexes: Impact of ligand type and receptor activation state Likewise, the relative importance of receptor activation state and ligand function differences have also This study compares performance when docking ligands of varied function into varied GPCR activation states , with higher accuracy expected when docking agonists into active state structures and inverse agonists or antagonists into inactive state structures.

Read about the newest discoveries in GPCR research 🙌 Save the dates: November 2 - 4: We're sponsoring success Sosei and PharmEnable extend neurological disease drugs hunt Sosei Heptares’ President & CEO Chris SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

Save the dates: November 2 - 4: We're sponsoring the GPCR Retreat and would love to meet you there! USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses State-dependent Topline Safety and Tolerability Data from Proof-of-Concept Studies Sosei Heptares’ President & CEO Chris SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

This week's highlight includes congrats to Omolade Otun, Chris de Graaf, Cherine Bechara, et al. for We are pleased to announce the scheduled dates for our highly anticipated courses led by Dr. Pharmacology in Drug Discovery I - Techniques for Effective Lead Optimization of Candidate Molecules Dates of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate Selection Dates Take advantage of the chance to showcase your creativity by participating in the Logo Contest.

Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian Bender , Chris Insights into the Activation Mechanisms of 5-HT2A Receptors Investigating the Effect of GLU283 Protonation State

INV-202, an Oral, Peripherally-acting CB1 Inverse Agonist, in Patients with Diabetic Kidney Disease Chris

either as homodimers or heterodimers, with distinct conformations in both their inactive and active states ligands produce different signaling outcomes depending on the receptor conformation or dimerization state As a result, dimerized SecR receptors exhibit higher rates of G protein activation and release, improving Additionally, the dimeric state allows rotational movement of the receptor's extracellular domain (ECD Tate, New insights into GPCR coupling and dimerisation from cryo-EM structures.  

Some Nbs that have been use for GPCR research are: Nb80: This nanobody stabilized an active-state conformation activation and investigate the role of specific regions in the switching between different conformational states extracellular surface of the Rhodopsin receptor and stabilizes the photo-activated receptor in a ground-state-like G., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor.

and intracellular responses GPCR signaling is a complex process modulated by protein conformational states Probing GPCR and β-Arrestin conformational states: methods and implications The formation of functional complexes involving GPCRs and β-arrestins hinges on their specific conformational states, influenced protein and has evolved to achieve resolutions comparable to X-ray crystallography (García-Nafría, J., & Tate Understanding how specific active conformational states influence the interaction or dissociation of

If you participated in our symposiums, please take a moment to complete this survey. GPCR University Save the date for our upcoming workshop, starting May 9th, 2024, featuring Dr.  Those on the waitlist will be notified first of the course dates, so hurry. Dr. Myers Squibb GPCR Events, Meetings, and Webinars March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

If you attended our 2023 Symposia, please take a moment to complete this survey. Dr. cellular signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism State-dependent Biagon Officially Incorporated In The State Of Illinois Septerna divulges new TSHR antagonists for hyperthyroidism March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

GPCR University We are excited to announce the dates for our upcoming courses led by Dr. Early-bird registration for premium Ecosystem members opens on July 31st, so mark your calendars and take Pharmacology in Drug Discovery I - Techniques for Effective Lead Optimization of Candidate Molecules Dates of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate Selection Dates Financial Results G-Protein Coupled Receptors Global Market 2024 To Reach $4.09 Billion By 2028 At Rate

Save the dates: November 17: Join our final Dr. Mobilization Using Propranolol with GPC-100 Sosei Heptares to Host R&D Day Highlighting its Innovative R&D and Late-Stage SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

August 2022 "Background and purpose: Vascular tone is regulated by the relative contractile state of Several integrins directly modulate VSMC contraction by regulating calcium influx through L-type voltage-gated

Take a few minutes and dive into our GPCR coverage! Our recent Dr. Save the dates: November 2 - 4: We're proud sponsors of the GPCR Retreat and can't wait to meet you there SLAS2024 International Conference and Exhibition March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 5 - 10, 2024

Additionally, if you participated in our Symposia in 2023, please take a moment to fill out this survey Protein-Coupled Receptors: Integrating Enhanced Sampling Molecular Dynamics Simulations and Markov State March 13 - 15 | 9th German Pharm-Tox Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

Save the dates: February 8 - 29: Join Dr. GPCR University's live Zoom sessions hosted by Dr. distinct dependence on arrestins and G proteins A method for structure determination of GPCRs in various states | 3rd GPCRs - Targeted Drug Discovery Summit March 23 - 24, 2024 | Ligand Recognition and Molecular Gating Seminar March 24 - 29, 2024 | Ligand Recognition and Molecular Gating Conference April 1 - 4, 2024 |

The results were striking: AlphaFold2 outperformed homology models, achieving a 60% hit rate for compounds To fully understand GPCR behavior and optimize drug targeting across multiple receptor states, experimental or NMR are still essential for confirming predictions, refining models, and exploring the functional states