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Immunology Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure Published date April 1, 2023 Abstract " Aims: A causal link between non-ischaemic heart failure (HF) and humoral autoimmunity against G-protein-coupled receptors (GPCR) remains unclear except Methods: Ninety-five non-ischaemic HF patients undergoing transcatheter endomyocardial biopsy and 60 Tags Chronic non-ischaemic heart failure , Heart failure , Pathophysiology .

< GPCR News < GPCRs in Oncology and Immunology From odor to oncology: non-canonical odorant receptors chemoreceptors, have been increasingly recognized for their presence and diverse functions in various non-nasal Alongside the canonical GPCR odorant receptors, dysregulation of non-canonical odorant receptors such The roles of these non-canonical chemoreceptors in cancer are complex, with some receptors promoting These findings shed light on the potential of non-canonical odorant receptors as therapeutic targets

Program Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical

Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid

governs macrophage migration during tissue inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or

deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts in response to chronic expression was also observed in other organs affected by fibrosis, including the kidney, liver, and heart

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation 2024 Abstract " Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small

It turns out that it was signal transduction, and he worked on the signaling cascades involved in heart failure.

expiratory volume, airflow obstruction and increased mucus production in asthma; loss of sense of smell in chronic Further research is needed to better understand the neuroimmune mechanisms that underlie chronic, sustained ligand 17 , CCL17 , CGRP , CIU , COPD , CRSsNP , CRSwNP , CSF2 , CSU , Calcitonin gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease , Chronic rhinosinusitis with nasal polyps , Chronic rhinosinusitis without nasal polyps , Chronic spontaneous urticaria , Colony stimulating factor

/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small family, G protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell

There, I completed a PhD in biochemistry exploring the non-canonical functions and possible novel mechanisms research focuses on investigating GPCR signaling and trafficking in the context of inflammation and chronic signalling and regulation, specifically in the context of pain and inflammation, and how his PhD research on non-canonical overcoming fluctuating confidence levels during his PhD journey, emphasizing the importance of viewing failures They also highlighted the benefits of maintaining a supportive network and engaging in non-lab activities

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Dopamine-Mediated Motor Recovery after Ischemic

focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center.

protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer , Chronic

has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic previously unrecognized cardiac-expressed GPCRs in the regulation of physiologic/pathologic function in the heart

focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center."

There is increasing evidence for an autoimmune aetiology in post-infectious Myalgic Encephalomyelitis/Chronic Anne Krüger , Markus Tölle , Carmen Scheibenbogen Tags GPCR-antibodies , Myalgic Encephalomyelitis/Chronic

GPCRs in Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure

Bangalore, India, to investigate the mechanisms behind rare mitochondrial diseases, which can lead to heart failure, muscle fatigue, and neurodegenerative disorders.

In this institution dear to the heart of GPCR enthusiasts given that its faculty personnel included Dr He also actively volunteers as an Associate Professor of the non-governmental organization Institut des

and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure signaling and show that a Gαs-PKA signaling axis promotes CD8+ T cell dysfunction and immunotherapy failure

Join me and learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol

He has held four Canada Research Chairs since 2001 and was previously a Heart and Stroke Foundation of Canada MacDonald Scholar (1998-2003) and Heart and Stroke Foundation of Ontario Career Investigator

at the University of Bonn, Germany, working initially on the role of prostaglandin receptor EP4 in chronic

McGill, his laboratory has two main axes of research: 1) Studying interindividual vulnerability to chronic

He has held four Canada Research Chairs since 2001 and was previously a Heart and Stroke Foundation of Canada MacDonald Scholar (1998-2003) and Heart and Stroke Foundation of Ontario Career Investigator

characterized the role of RGS4 and RGS5 in airway hyperresponsiveness and lung fibrosis in acute and chronic

July 3, 2024 Abstract "Development of type 2 diabetes mellitus (T2DM) is associated with low-grade chronic