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and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic obstructive pulmonary disease (COPD), atherosclerosis, asthma, and pancreatic cancer. Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer , Chronic obstructive pulmonary disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory disease.

The consequences of altered neuroimmune activity differ with tissue type and disease and include: skin and prurigo nodularis; airway inflammation/hyperresponsiveness, loss of expiratory volume, airflow obstruction adrenal medulla peptide 8-22 , Bullous pemphigoid , C-C motif chemokine ligand 17 , CCL17 , CGRP , CIU , COPD , CRSsNP , CRSwNP , CSF2 , CSU , Calcitonin gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease , Chronic rhinosinusitis with nasal polyps , Chronic rhinosinusitis without

News < GPCRs in Oncology and Immunology GPCRs and fibroblast heterogeneity in fibroblast-associated diseases About one-third of the commercially available drugs for various diseases target the GPCRs. architecture of the GPCRs and their intertwined signaling in pathological conditions such as idiopathic pulmonary Understanding the dynamics of GPCR signaling in fibroblasts with disease progression can help in the recognition of the complex interplay of different GPCR subtypes in fibroblast-mediated diseases.

Mechanisms Underlying Location Bias in GPCR Signaling Date & Time Saturday, November 4th / 8:40 AM Abstract mechanisms underlying biased agonism at GPCRs and its contribution inflammation and cardiovascular disease His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

His clinical focus is on pulmonary arterial hypertension, a disease of the pulmonary arterioles that causes right heart failure, and he serves as co-director of the Duke Pulmonary Vascular Disease Center

profiling of Transcription factor 21 expressing activated kidney fibroblasts Published date April 28, 2023 Abstract " Background and purpose: Activated fibroblasts deposit fibrotic matrix in chronic kidney disease (CKD approach: RNA sequencing and single cell qRT-PCR were performed on mouse kidneys after unilateral ureteral obstruction

However, the physiological functions of many GPCRs and the involvement of them in autoimmune diseases However, Gpr141 deficiency exacerbated disease conditions of experimental autoimmune encephalomyelitis , an autoimmune disease model for multiple sclerosis, with increased inflammation in the spinal cord. dendritic cells and that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory diseases."

receptor 2 governs macrophage migration during tissue inflammation Published date December 12, 2023 Abstract "Chronic inflammation is the underlying cause of many diseases, including type 1 diabetes, obesity, and non-alcoholic fatty liver disease. Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or

Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases Published date April 20, 2023 Abstract " The CC chemokine receptor 6 (CCR6) is a G protein-coupled receptor This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases

lineage of anti-thermogenic adipocytes with implications for adaptive thermogenesis during prolonged cold exposure Anastasia Georgiadi ADGRF5-mediated regulation of cardiac health and disease Douglas Tilley Netherlands; 2Department of Experimental Immunology, Amsterdam institute for Immunology and Infectious diseases Georgiadi on the web Endocrine Pharmacology Google Scholar ADGRF5-mediated regulation of cardiac health and disease has evolved to encompass their roles in regulating immune cell response to acute cardiac injury or chronic

Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases Published date November 20, 2023 Abstract "We show that the gut bacterial metabolites, short chain fatty pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc and promote disease how the gut microbiome may be affecting peripheral immune cells, and consequently Western lifestyle diseases Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein

< GPCR News < GPCRs in Oncology and Immunology Deciphering the genetic landscape of lumpy skin disease variable virulence through comprehensive genome sequence analysis in India Published date May 23, 2024 Abstract "Lumpy Skin Disease (LSD), a poxvirus disease affecting cattle, emerged in India in 2019 and intensified , V Gairola, D Poloju, S Gulzar, K P Singh, R K Singh, G K Sharma Tags Genome sequence , Lumpy skin disease

crystal deposition and kidney injury in oxalate nephropathy in female mice Published date July 11, 2023 Abstract While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher setting of oxalate-induced nephropathy, the lack of the proton-activated GPCR GPR4 does not influence disease Joller , Carsten A Wagner , Pedro Henrique Imenez Silva Tags G-protein-coupled receptors , acid-base , chronic kidney disease , hyperoxaluria , inflammation , kidney stones Source Contribute to the GPCR News Coming

Retreat Program < Back to schedule Cannabinoid compounds to augment L-DOPA treatment in Parkinson's Disease Date & Time Friday, November 3rd / 9:20 AM Abstract Coming Soon About Ali Salahpour "Dr.

and Genetic Preclinical Models of Ghrelin Receptor Functional Selectivity to Investigate Metabolic Disease Pathophysiology Date & Time Friday, November 3rd / 9:45 AM Abstract Coming Soon Authors and Affiliations GPCR biased signaling to design/develop new pharmacotherapeutics to treat reward- and metabolism-based diseases novel GPCR pharmacotherapies that improve efficacy and minimize side effects for diet-induced metabolic diseases

by inhibiting inflammation and promoting cell self-renewal in mice Published date December 8, 2023 Abstract " Background: Acute respiratory distress syndrome (ARDS) is a disease with high mortality and morbidity The RGS6 overexpression plasmid was constructed for transfection. qRT‒PCR was used to assess proinflammatory with the control group, we found higher mortality, more pronounced body weight changes, more serious pulmonary

Sponsors GPCR Retreat Program < Back to schedule Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease coupled receptors and their role in neurodegenerative disorders, including Alzheimer's and Huntington's diseases

Program < Back to schedule Biased agonism at the GLP-1 receptor: from structure to animal models of disease Date & Time Friday, November 3rd / 11:05 AM Abstract Coming Soon About Patrick Sexton " Patrick Sexton

Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid

Immunology C5aR2 receptor: The genomic twin of the flamboyant C5aR1 Published date November 1, 2022 Abstract context-dependent compared to the C5aR1, which has received enormous attention for its role in both acute and chronic inflammatory diseases.

markers, histology, and function in human non-ischaemic heart failure Published date April 1, 2023 Abstract ambiguous reports on incidences of GPCR autoantibodies, spurious correlations of autoantibody levels with disease they are correlated poorly or even inversely to haemodynamic, metabolic, and functional markers of disease Tags Chronic non-ischaemic heart failure , Heart failure , Pathophysiology .

dysbiosis in IBD patients: Potential role of GPR109A in macrophages Published date September 2, 2024 Abstract "Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract characterized

, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease work has been applied to studies encompassing neurological and psychiatric disorders, cardiovascular disease , obesity, diabetes, chronic pain and addiction. They highlighted the importance of fine-tuning the approach to suit different diseases and interdisciplinary The discussion also emphasized the need for a disease-specific approach, considering the clinical context

reaction networks are an important and emerging tool for the study of cell signaling networks involved in disease One promising potential application of such mathematical models is the study of how disease-causing mutations promote the signaling phenotype that contributes to the disease. and use model-driven explorations to uncover and explore multiple new areas for investigating this disease revealed the potential for previously unknown qualitative differences between seemingly interchangeable disease-promoting

in Oncology and Immunology Itaconate in host inflammation and defense Published date March 5, 2024 Abstract Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory diseases Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory diseases

modulator for favorable prognosis in HNSCC through machine learning Published date September 15, 2023 Abstract Among 41 patients treated at RP2D, a measurable residual disease-negative complete remission (MRD- CR 76%, without differences in MRD- CR rates, OS, or EFS between patients with or without FLT3-mutated disease Benefit was limited to patients with intermediate-risk disease (univariate analysis: P = .01 for OS; improves OS and EFS relative to CLAG-M alone, with benefits primarily in patients with intermediate-risk disease

granules for the treatment of prostatitis and benign prostatic hyperplasia Published date June 28, 2024 Abstract compounds in Jinqiancao granules and their target mechanisms for the potential treatment of the two diseases networking were utilized to establish a general correlation between Jinqiancao granules and the two diseases Five compounds showed weak antagonistic activity on M3, which was confirmed to be a disease target by experiment-based network reflected a pharmacological relationship between Jinqiancao granules and the two diseases

Nicole Perry-Hauser ADGRCs in glutamatergic synapse formation, maintenance and degeneration Yimin Zou Abstract Initial impairment of synaptic functions, which occurs early in Alzheimer’s disease, and subsequent massive ADGRC3 are required for the restoration of glutamatergic synapses in prefrontal cortical neurons of chronically My research focus is the mechanisms of neural circuit development, function and disease." the web UC San Diego Antibody-drug conjugates targeting CD97 in glioblastoma Dimitris Placantonakis Abstract