the evidence obtained in this study proposes novel molecular mechanisms in which β-arrestin exhibits spontaneous unstimulated and stimulated conditions: Unstimulated condition: Inactive β-arrestin in the cytosol spontaneously Stimulated condition in the presence of a stimulated receptor: Spontaneous insertion into the plasma

Until recently, itch pathophysiology was poorly understood and treatments were poorly effective in relieving itch. Current progress in our knowledge of the itch processing, the numerous mediators and receptors involved has led to a large variety of possible therapeutic pathways. Currently, inhibitors of IL-31, IL-4/13, NK1 receptors, opioids and cannabinoids, JAK, PDE4 or TRP are the main compounds involved in clinical trials. However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored. Read full article

autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark of refractory chronic

expiratory volume, airflow obstruction and increased mucus production in asthma; loss of sense of smell in chronic Further research is needed to better understand the neuroimmune mechanisms that underlie chronic, sustained ligand 17 , CCL17 , CGRP , CIU , COPD , CRSsNP , CRSwNP , CSF2 , CSU , Calcitonin gene-related peptide , Chronic idiopathic urticaria , Chronic obstructive pulmonary disease , Chronic rhinosinusitis with nasal polyps , Chronic rhinosinusitis without nasal polyps , Chronic spontaneous urticaria , Colony stimulating factor

Importantly, GPCRs are naturally nanosized, and spontaneously formed nanoaggregates of GPCRs (natural SIGNIFICANCE: GPCRs as molecular targets for the majority of marketed drugs are naturally nanosized, and even spontaneously

protein-coupled receptor (GPCR) and plays important roles in various inflammatory diseases and cancers, including chronic Yishi Xie , Wenbin Kuang , Dawei Wang , Kai Yuan , Peng Yang Tags CXCR2 , CXCR2 antagonist , Cancer , Chronic