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Welcome to the new and improved Dr. GPCR Ecosystem. In this mini video course, I want to walk you through our new website and show you what the ecosystem has to offer to its members.

Here we demonstrate that a similar approach can be employed to rescue mutant follicle-stimulating hormone Seventeen FSHR mutations described in patients with reproductive dysfunction were expressed in HEK 293T reduced to ≤18% of wild-type (WT) for 11, modestly reduced to 66% to 84% of WT for 4, and not reduced for 2. expression, restoration to ≥57% of WT levels was achieved for 6 by treatment with 1 µM CAN1404 for 24

September 2022 "In the Wnt-β-catenin pathway, Wnt binding to Frizzled (Fzd) and LRP5 or LRP6 (LRP5/6) Using purified Fzd proteins reconstituted in lipid nanodiscs, we investigated the factors that promote Our findings suggest a positive feedback loop in which Wnt-stimulated local PI(4,5)P2 production enhances

We found that astrocyte Gi -DREADD stimulation using clozapine N-oxide (CNO) inhibits neuroinflammation Subsequent experiments using primary astrocyte cultures revealed that Gi -DREADD stimulation significantly

2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators rhinosinusitis with nasal polyps , Chronic rhinosinusitis without nasal polyps , Chronic spontaneous urticaria , Colony stimulating factor 2 , DRG , Dorsal root ganglion , EGPA , EMA , EoE , Eosinophilic esophagitis , Eosinophilic IRF1 , IgE , Immunoglobulin E , Innate lymphoid cell , Interferon gamma-AS1 , Interferon regulatory factor chemoattractant protein-4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU , NP , Na(v) , Nasal polyps , Nerve growth factor

G protein coupled receptor transcripts in human immune cells and platelets Published date September 27 , and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets. On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206). We believe our data should stimulate studies of receptor function and contribute to drug development.

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling Published date September 1, 2023 Abstract "Neuropeptide FF (NPFF The pathogenesis of EOC can be regulated by many local factors, including neuropeptides, through an autocrine In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression through the NPFFR2-mediated ERK1/2 signaling pathway."