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4 items found for "Cytotoxicity"

Ultrasensitive dose-response for asbestos cancer risk implied by new inflammation-mutation model
fibers in humans and experimental animals are thought to involve modes of action driven by mutations, cytotoxicity-associated Author Kenneth T Bogen Tags Asbestos , Cytotoxicity , Inflammation , Lung cancer , Mesothelioma , Mutation
Systems Pharmacodynamic Model of Combination Gemcitabine and Trabectedin in Pancreatic Cancer Cells. Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways
In a prior study, we reported the synergistic cytotoxic effects of gemcitabine and trabectedin on pancreatic
Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
bronchopulmonary aspergillosis , Allergic fungal rhinosinusitis , Allergic rhinitis , Antibody-dependent cellular cytotoxicity
Coronavirus Porcine Epidemic Diarrhea Virus Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux
IL-8 deletion restrained cytosolic calcium (Ca2+), whereas IL-8 stimulation improved cytosolic Ca2+. PEDV internalization and budding were obvious reductions when cytosolic Ca2+ was abolished in the presence Further study revealed that the upregulated cytosolic Ca2+ redistributes intracellular Ca2+. PEDV induces IL-8 expression to elevate cytosolic Ca2+, promoting its infection. We found that IL-8 expression improved cytosolic Ca2+ in epithelia, facilitating PEDV rapid internalization