Studies have indicated that transmembrane helix 7 (TMH7) and the highly conserved NPXXY motif can be

Here, we demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical lead backbone cyclic peptide, was selected out of a mini-library, directed toward PAR2&4 PH-binding motifs

GPCR internalization undergoes a series of strict regulations, especially by posttranslational modifications

The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed The DRF motif is restricted to mammals, turtles, and frogs, while the DRY motif, typical in other CKRs Most birds exhibit the DRL motif. These substitutions at the DRF motif affect the receptor-Gi/o protein interaction. /DRF/DRL motif , GC-rich gene , GPCR , Mucosal immunology , Tissue-resident memory T cells (TRM) .

two datasets, a mutation enrichment in cancer patients was observed among class-specific conserved motifs in GPCRs such as the Class A "DRY" motif. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >

< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma conditions Published date September 20, 2023 Abstract "Prenylation is an irreversible post-translational modification GPCR News and get weekly notifications about the GPCR field Share < Previous Next >