Studies have indicated that transmembrane helix 7 (TMH7) and the highly conserved NPXXY motif can be

Here, we demonstrate identification of a pleckstrin-homology (PH)-binding motif within PAR4, critical lead backbone cyclic peptide, was selected out of a mini-library, directed toward PAR2&4 PH-binding motifs

GPCR internalization undergoes a series of strict regulations, especially by posttranslational modifications

September 2022 Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal possible role of the K101 residue in a cholesterol recognition/interaction amino acid consensus (CRAC) motif

G protein-coupled receptor interactions and modification of signalling involving the ghrelin receptor Known roles of GHSR1a now extend to regulation of neurogenesis, learning and memory, gastrointestinal motility , glucose/lipid metabolism, the cardiovascular system, neuronal protection, motivational salience, and

sites and domains within SMO and relate them with known cholesterol-binding sequence and structure motifs CRD) and the intracellular domain (ICD), are through residues belonging to known cholesterol-binding motifs with lower TM cholesterol-binding domains are governed by the presence of multiple cholesterol-binding motifs These analyses have also helped to identify and define a strict cholesterol consensus motif (CCM), which

The recruitment likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction

transcriptomics and proteomics have provided insights into the expression patterns and post-translational modifications For example, we know that transmembrane helices move during receptor activation and that the DRY motif

domains (TMs 1-7), a bridge between TM7 and the N-terminus (Szpakowska, Bercoff et al. 2014) and a TxP motif The subfamily-defining CC/CXC/CX3C/XC motif is located in the N-loop and forms two conserved disulfide which include the W6.48xP6.50 motif and the P5.50I3.40F6.44 motif which are located below the 7TM cavity in the middle of the transmembrane region, and the N7.49P7.50xxY7.53 and D3.49R3.50Y3.51 motifs, located However, in US28, the factors stabilizing the inactive state of this motif are absent.

Constituent structural motifs cooperatively transform ligand selectivity into specific functions, thus conceptualizing the primacy of the 3D structure over individual motifs of receptors.

Differential Responses of the GLP-1 and GLP-2 Receptors to N-Terminal Modification of a Dual Agonist. A key GPCR phosphorylation motif discovered in arrestin2⋅CCR5 phosphopeptide complexes.

As GTP stabilizes and migrates towards the P loop, it causes the TCAT motif to shift, a key movement This helix undergoes significant restructuring—it breaks and reforms closer to the TCAT motif, which

In addition to the RGS domain, RGS proteins also contain a range of other structural motifs that are protein-binding domain, the DEP (Dishevelled, Egl-10 and Pleckstrin domain) domain, and the GoLoco motif have revealed that the interaction between RGS proteins and GPCRs is mediated by a range of structural motifs and GPCRs is highly specific and tightly regulated; mutations in the RGS domain and other structural motifs

C-X-C motif chemokine ligand 12 (CXCL12) has two receptors: C-X-C chemokine motif receptor 4 (CXCR4)

C-X-C motif chemokine receptor 4 (CXCR4), a G-protein-coupled receptor (GPCR), has one identified natural

Like those, they have a derived NPxxY motif.

Unusual phototransduction via cross-motif signaling from Gq to adenylyl cyclase in intrinsically photosensitive Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders

This review will focus in particular on pepducins designed from protease-activated receptors, C-X-C motif

class A GPCRs and existing experimental data in the literature as constraints, we pinpointed conserved motifs

KO cells, and a receptor containing a mutated putative adaptor protein complex 2 (AP-2) interaction motif

N-terminal mutants of αqQ209L, termed PM-restricted αqQ209L, in which the addition of membrane-binding motifs

Superconserved receptors expressed in the brain: Expression, function, motifs and evolution of an orphan Lysine 101 in the CRAC Motif in Transmembrane Helix 2 Confers Cholesterol-Induced Thermal Stability to

We further demonstrate using NMR spectroscopy that a polyproline motif within arrestin-3 interacts directly

GPCR Activation and Signaling G protein activation via chemokine (C-X-C motif) receptor 4 and α1b -adrenoceptor

enriched for highly impactful, recurrent mutations at selected cognate positions of known functional motifs

Structural snapshots uncover a key phosphorylation motif in GPCRs driving β-arrestin activation.

synthesis in the endoplasmic reticulum, many of these receptors are cleaved at the GPCR Proteolysis Site motif analysis of the Stalk peptide of the aGPCR family was performed highlighted a new hydrophobic conserved motif

Function Structure of endothelin ETB receptor-Gi complex in a conformation stabilized by unique NPxxL motif