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174 items found for "DRY/DRF/DRL motif"
- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
The unique DRF motif of CXCR6 facilitates leukocyte adhesion by interacting with cell surface-expressed The DRF motif is restricted to mammals, turtles, and frogs, while the DRY motif, typical in other CKRs Most birds exhibit the DRL motif. These substitutions at the DRF motif affect the receptor-Gi/o protein interaction. /DRF/DRL motif , GC-rich gene , GPCR , Mucosal immunology , Tissue-resident memory T cells (TRM) .
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
two datasets, a mutation enrichment in cancer patients was observed among class-specific conserved motifs in GPCRs such as the Class A "DRY" motif. GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
< GPCR News < GPCRs in Oncology and Immunology CaaX-motif-adjacent residues influence G protein gamma conditions Published date September 20, 2023 Abstract "Prenylation is an irreversible post-translational modification GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Involvement of Protease-Activated Receptor2 Pleckstrin Homology Binding Domain in Ovarian Cancer: Expression in Fallopian Tubes and Drug Design
These motifs associate with PH-signal proteins via launching a discrete signaling network in cancer. selected a compound from a library of backbone cyclic peptides generated toward the PAR PH binding motif This is the first demonstration of the involvement of PAR PH binding motif signaling in ovarian cancer GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
Both receptors contain PSD-95/Discs-large/ZO-1 homology (PDZ) motifs in their C-terminal tails through Deleting the GPR30 C-terminal PDZ motif (-SSAV) does not interfere with the receptor complex, indicating GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory diseases and cancers
CXCR2 antagonists in inflammatory diseases and cancers Published date March 15, 2023 Abstract " C-X-C motif GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- The β2-adrenergic receptor associates with CXCR4 multimers in human cancer cells
The C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis
studies in mice, we show that GPR143 promotes metastasis by secreting exosomes and increasing cancer cell motility a mechanism for regulating the exosomal proteome and demonstrate its ability to promote cancer cell motility GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Itaconate in host inflammation and defense
function of diverse proteins intracellularly to influence metabolism, oxidative response, epigenetic modification GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Comparative analysis of the occupancy of Histone H3 Lysine 4 methylation in the cells treated with TGFβ and Interferonγ
each other's signalling, it would be of utmost importance to find out the regions undergoing histone modification GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Using genetic modification and pharmacological strategies we demonstrate mechanistically that this ATP-driven GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Natural carboxyterminal truncation of human CXCL10 attenuates glycosaminoglycan binding, CXCR3A signaling and lymphocyte chemotaxis, while retaining angiostatic activity
As a consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural Sofie Struyf , Paul Proost Tags Angiogenesis , CXCL10 , Chemokine , Lymphocytes , Posttranslational modifications GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Lactate receptor GPR81 drives breast cancer growth and invasiveness through regulation of ECM properties and Notch ligand DLL4
subjected to RNA-seq analysis, 3D growth, in situ- and immunofluorescence analyses, and cell viability- and motility GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Neuroimmune interplay during type 2 inflammation: symptoms, mechanisms and therapeutic targets in atopic diseases
dermatitis , BAM8-22 , BP , Beta chain , Bovine adrenal medulla peptide 8-22 , Bullous pemphigoid , C-C motif GPCR News and get weekly notifications about the GPCR field Share < Previous Next >
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Many ADGRs are autoproteo-lytically cleaved at the GPCR proteolysis site (GPS), an HXS/T motif within unique structural features that are important for autoproteolytic cleavage, beyond the canonical HXS/T motif
- A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice
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- Neutrophils are itching to specialize
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- Emerging GPCR targets for AUD: Insights from preclinical studies
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- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
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- Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy
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- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
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- Ep 56 with Dr. Adriano Marchese
that govern spatial and temporal regulation of GPCR signaling by -arrestins and post-translational modifications
- Retreat | Dr. GPCR Ecosystem
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- Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19
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- Noval insights and therapeutic strategies for tumor-induced kidney pathologies
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- GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
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- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
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