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December 2021 "Dame Carol Robinson DBE, FRS, FRSC, FMedSci, Oxford University’s first female Professor

December 2021 OMass Therapeutics's founder, Carol Robinson, has been awarded the prestigious Louis-Jeantet Benjamin Franklin Medal in Chemistry from The Franklin Institute "Huge congratulations to our founder, Carol Robinson, who has been awarded the prestigious Louis-Jeantet Prize for Medicine 2022 by the Louis-Jeantet

Industry News Professor Dame Carol Robinson Received 2023 ASMS John.B.Fenn Award Exscientia Announces Exscientia to Present Data Highlighting Pipeline and Precision Medicine Platform at AACR Fast Company has named

February 2022 "Switzerland Today, InterAx Biotech is pleased to announce that Carola Weiss has joined Carola Weiss is a Senior Executive with more than 20 years of international experience in the biopharmaceutical Carola Weiss’ professional career brings deep expertise in business development, marketing & sales, licensing

☕ We are excited to announce our rescheduled Dr. GPCR Virtual Cafe session with Dr. Matthew E. on Friday, October 7th at 1 PM ET. Don't miss the chance to listen to his latest research on the field. It's a great opportunity to get warmed up for the upcoming Summit starting the next Monday. Get your ticket today on Eventbrite! ➡https://bit.ly/3CmntVn

Biology, Vlaams Instituut Biotechnologie, at the Vrije Universiteit Brusle, Brussels, Belgium, has been named

September 2022 "Morphine, the most widely used analgesic, relieves severe pain by activating the μ-opioid receptor (MOR), whereas naloxone, with only slight structural changes compared to morphine, exhibits inhibitory effect, and is used to treat opioid abuse. The mechanism by which the MOR distinguishes between the two is unclear. Molecular dynamics (MD) simulations on a 1-μs time scale and metadynamics-enhanced conformational sampling are used here to determine the different interactions of these two ligands with MOR: morphine adjusted its pose by continuously flipping deeper into the pocket, whereas naloxone failed to penetrate deeper because its allyl group conflicts with several residues of MOR. The endogenous peptide ligand endomorphin-1 (EM-1) underwent almost no significant conformational changes during the MD simulations. To validate these processes, we employed GIRK4S143T, a MOR-activated Gβγ-protein effector, in combination with mutagenesis and electrophysiological recordings. We verified the role of some key residues in the dynamic recognition of naloxone and morphine and identified the key residue I322, which leads to differential recognition of morphine and naloxone while assisting EM-1 in activating MOR. Reducing the side chain size of I322 (MORI322A) transformed naloxone from an inhibitor directly into an agonist of MOR, and I322A also significantly attenuated the potency of MOR on EM-1, confirming that binding deep in the pocket is critical for the agonistic effect of MOR. This finding reveals a dynamic mechanism for the response of MOR to different ligands and provides a basis for the discovery of new ligands for MOR at the atomic level." Read more at the source #DrGPCR #GPCR #IndustryNews

March 2022 Crinetics Pharmaceuticals Expands Executive Team With Appointment Of James Hassard As Chief therapeutics for rare endocrine diseases and endocrine-related tumors, today announced the appointment of James

We've refreshed the schedule and can’t wait for you to join us on these new dates. New Course Dates: Principles of Pharmacology I :  October 3, 10, 17, 24 (four sessions) Principles GPCR Event Spotlight    11th Adhesion GPCR Workshop    Location:  Mexico City Dates:  October 23-25,

pharmacology' Yao Lu and colleagues work on 'Molecular insights into orphan GPCRs relevant to schizophrenia' Carole Save the dates: September 7 - 8: Join the 3rd ECI GPCR Symposium, an event by and for early career investigators

This Week’s Highlights: Celebrating Excellence:   Patrick Sexton  and Arthur Christopoulos  Named Among research Trinh Trung Duong Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli and models of physiological ligand complexes Luis P Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli GPCR Events You can begin organizing and marking a few dates in 2025 .

August 2022 "THOUSAND OAKS, Calif. and SAN CARLOS, Calif., Aug. 4, 2022 /PRNewswire/ -- Amgen (NASDAQ

ChemoCentryx Announces EU Approval of TAVNEOS® (avacopan) for the Treatment of ANCA-Associated Vasculitis "SAN CARLOS

Adopted by European Medicines Agency (EMA) Committee for Medicinal Products for Human Use (CHMP) "SAN CARLOS

Save the dates: November 17: Join our final Dr. Kathleen Caron. Check out the weekly Classified GPCR News from October 23rd to 29th, 2023.

Save the date: TOMORROW - November 17: Don't miss out on our final Dr. Kathleen Caron, as our video guest, subscribe now!

GPCRs, Ion Channels, and Transport Proteins (March 24 - 29, 2024) GPCR Jobs NEW Postdoctoral Fellow, Caron

lab team developed fluorescent analogues for real-time binding studies of orphan GPCR GPR3: Save the dates Kathleen Caron. Check out the weekly Classified GPCR News from October 30 to November 4, 2023. GLP-1 Receptor Agonist PF-06954522 into a Phase 1 Trial Andrew Hopkins Inducted into RSC BMCS Hall of Fame

Senior Scientist- Membrane Technologies NEW Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

Carl F. Cori and Mrs. Cori. Nobel Prize: Three Named for Medicine, Physiology Award. Sir James W. Sir James W. Sir James Whyte Black OM. 14 June 192422 March 2010.

Surgery Senior Scientist- Membrane Technologies Computational Protein Design (GPCR) Postdoctoral Fellow, Caron

., Caron, M. G., Lefkowitz, R. J., & Strader, C. D. (1986).

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in

to the Principles of Pharmacology I & II courses, and we can’t wait for you to join us on these new dates Dates:  October 3 to 24, 2024 (four sessions) Topics:  Measuring pharmacologic activity, mechanisms of Dates:  October 31, November 7 - 14 -21, and December 5, 2024 (five sessions) Topics:  New cellular assays GPCR Event Spotlight    11th Adhesion GPCR Workshop    Location:  Mexico City Dates:  October 23-25,

Get ready to save the dates! Dr. Dates:  September 5 to 26, 2024 What You’ll Learn during the four sessions: How to measure pharmacologic Dates:  October 3 to 31, 2024 What You’ll Master during the five sessions: Utilizing new cellular assays innovative drug profiles GPCR Event Highlight  11th Adhesion GPCR Workshop    Location : Mexico City Dates

August 2022 "GPCRs in Medicinal Chemistry Event 8th RSC / SCI symposium on GPCRs in Medicinal Chemistry Dates October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links Registration closing dates

The story behind how Dr.GPCR came to be, the people behind the process, the great anecdotes, and what

We will provide a new rescheduling date soon. #gpcr #drgpcr