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< GPCR News < GPCRs in Oncology and Immunology miR-19a may function as a biomarker of oral squamous cell While much progress has been made in understanding various sensory modalities, the sense of hygrosensation By examining the expression of known and novel marker genes, we validated the identity of these clusters Understanding the mechanisms underlying hygro- and thermosensation may shed light on the broader understanding Authors Jijun Chen , Liang Wang , Danhua Ma , He Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu

Malden, MA 02148 Email Hello@DrGPCR.com Phone 646-508-3568 Social Media First Name Last Name Email Message

Authors Brian Kim , Marc E Rothenberg , Xin Sun , Claus Bachert , David Artis , Raza Zaheer , Yamo Deniz Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 , MRGPRX1 , Mas-related family of G protein-coupled receptor 11 , Mas-related family of G protein-coupled receptor X1 , Mas-related family of G-protein-coupled receptor 3 , Mas-related family of G-protein-coupled Administration , VIP , Vasoactive intestinal peptide , Voltage-gated sodium channel , gamma chain , mAb

Finally, we review the progress of clinical trials of GPCR-targeted drugs for cancer treatment, which may This expanded understanding of the role of GPCRs may shed light on the mechanisms underlying tumor progression Authors Guang-Hong Qiu, Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy

cancer prognosis Published date June 18, 2024 Abstract " Background: Ovarian cancer (OV) is a common malignant Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic model , epithelial Source

Utilizes Chemokine Interleukin-8 to Facilitate Viral Replication by Regulating Ca2+ Flux Published date May Authors Xuyang Guo , Yingtong Feng , Xiaojing Zhao , Shuang Qiao , Zhiqian Ma , Zhiwei Li , Haixue Zheng

multidisciplinary Chemical Biology team based at the recently established US R&D hub in Lexington, MA Originally from Łódź, Poland, Jacek completed his Master's degree in Biology, specializing in Biochemistry His research aimed at understanding molecular mechanism through which rare genetic variation may lead GPCR AI Summary AI-generated content may be inaccurate or misleading. Always check for accuracy. They also shared their appreciation for documentaries showcasing manufacturing processes and the value

Adriano Marchese About Dr. Adriano Marchese Adriano Marchese is a Professor of Biochemistry at the Medical College of Wisconsin. Adriano Marchese on the web Twitter LinkedIn Google Scholar Website Dr.

GPCR Podcast << Back to podcast list Martin Audet About Dr. Martin Audet Structural biologist, pharmacologist, and a professor of pharmacology at Université de Sherbrooke Martin Audet on the web LinkedIn Twitter Sherbrooke University Google Scholar Dr.

Matthew Eddy About Dr. Matthew Eddy Matthew Eddy earned his BA in Chemistry from Oberlin College, where he trained with solid-state NMR expert Professor Manish Mehta . He then earned his Ph.D. in physical chemistry from the Massachusetts Institute of Technology, training Matthew Eddy on the web Website Dr.

Maria Waldhoer About this episode Dr. Maria Waldhoer is originally from Austria. GPCRs led Maria to Thue W. After working in the US and at the University in Graz in Austria, Maria worked several years at Novo on GPCRs make her a strong and dedicated scientific leader. Maria Waldhoer on the web LinkedIn InterAx Biotech Pubmed Dr.

GPCR Podcast << Back to podcast list Mark Schmeizl About Mark Schmeizl Mark leverages 30 years in various Mark believes professional placement should be about matching talented people with companies where they will thrive, “when the match is right, the results are astonishing.” Mark Schmeizl on the web Website LinkedIn Dr.

Katarzyna Marcinkiewicz About Dr. Katarzyna Marcinkiewicz "Katarzyna is a Senior Editor at Nature Communications, which she joined in April Katarzyna Marcinkiewicz on the web LinkedIn Nature The Spectator Dr.

Mark Connor About Dr. Mark Connor Undergraduate BSc with Honours in Pharmacology from University of Sydney (1987, snake neurotoxins Postdoc with Graeme Henderson (Bristol, opioids and Ca signaling) and Mac Christie (Sydney, opioids in , Vollum Institute Portland (visiting scientist with Ed McCleskey, sensory neuron properties); Pain Management Mark Connor on the web Researchers Twitter Google Scholar Dr.

Masha Niv About this episode Dr. Masha earned her Bachelor’s degree in chemistry, followed by a direct Ph.D. at the Institute of Chemistry Masha Niv on the web Niv Lab LinkedIn Twitter Pubmed Google Scholar Dr.

Marta Filizola About Dr. Marta Filizola Dr. Marta Filizola is the Sharon & Frederick A. modeling, bioinformatics, cheminformatics, molecular dynamics simulations, free-energy perturbations, machine A native of Italy, she received her Bachelor’s and Master’s degrees in Chemistry from the University Marta Filizola on the web Icahn School of Medicine at Mount Sinai Filizola Lab Wikipedia Twitter Linkedin

Jean Martin Beaulieu About Dr. Jean Martin Beaulieu Dr. These receptors belong to the super-family of G-protein coupled receptors (GPCR), the major molecular In particular, D2R is the main pharmacological target of antipsychotic drugs prescribed for schizophrenia Jean Martin Beaulieu on the web University of Toronto Google Scholar LinkedIn ResearchGate Dr.

Stuart Maudsley About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz Maudsley continued his scientific journey with the award of the highly-valued Odysseus Program Type I Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook

Fiona Marshall About this episode Fiona Marshall got fascinated with GPCRs after attending a lecture Heptares , a GPCR-focused drug discovery and development biotechnology company, Fiona and her team made Marshall is the VP Head of Neuroscience Discovery and Head of Discovery UK, Global Head of Neuroscience Fiona Marshall on the web LinkedIn Twitter Google Scholar MSD UK Dr.

Stuart Maudsley About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz Maudsley continued his scientific journey with the award of the highly-valued Odysseus Program Type I Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook

Stuart Maudsley About Dr. Stuart Maudsley Stuart graduated from the University of Leeds in the U.K. with a First Class Honors degree Maudsley was awarded a Howard Hughes Medical Institute Fellowship to train with Professor Robert Lefkowitz Maudsley continued his scientific journey with the award of the highly-valued Odysseus Program Type I Stuart Maudsley on the web Maudsley Lab LinkedIn Google Scholar ResearchGate Maudsley Lab on Facebook

Immunology Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy Together, this study suggests inhibition of the Gαq protein and restriction of ascites accumulation as maintenance Fulei Wuchu, Minal Nenwani, Zachary Fischer, Alec Sunshine, Zequan Lin, Linh Tran, Deepak Nagrath, Mats Ljungman, Katherine Maturen, Analisa DiFeo, David Nordsletten Tags G-protein coupled receptors (GPCR

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration Macrophages are continuously recruited to tissues during chronic inflammation where they exacerbate or We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration Moreover, we established the applicability of our zebrafish findings to mammals by showing that macrophages

< GPCR News < GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the VSMCs treated with BC-CM displayed enhanced pro-inflammatory phenotype and higher adherent with macrophages

adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages Published date May 28, 2023 Abstract "Adenosine 2a receptor (A2aR), a typical GPCR with a high affinity (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages studies demonstrate that A2aR on LUAD cells drives TAMs migration and polarization, and blockade of A2aR may Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages Finally, the secretome from siGPR109A M1 macrophages reduced the gene and protein expression of COL1A1 Authors Cristina Bauset, Miguel Carda-Diéguez, Andrea Cejudo-Garcés, Elena Buetas, Marta Seco-Cervera , Dulce Carolina Macias-Ceja, Francisco Navarro-Vicente, Juan Vicente Esplugues, Sara Calatayud, Álex Mira, Dolores Ortiz-Masiá, María Dolores Barrachina, Jesús Cosín-Roger Tags GPR109A , IBD , Metabolite-sensing

GPCRs in Oncology and Immunology Respiratory infections predominate after day 100 following B-cell maturation therapy Published date September 26, 2023 Abstract "Infections are an important complication after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy and risks may differ between at the recommended phase 2 dose) for relapsed/refractory multiple myeloma between November 2016 and May and diagnosis of an early respiratory infection are risk factors for late respiratory infections that may

protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21, 2024 Abstract "Colorectal cancer (CRC) remains a major global cause