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118 items found for "Dario A A Vignali"
Posts (95)
- Regulators of G-protein signaling: essential players in GPCR signaling
Regulator G protein Signaling (RGS) proteins are critical components of the intracellular signaling pathways and amplitude of GPCR signaling. Another signaling pathway related to RGS4 involves the regulation of the immune response. Senese, N.B., et al., Regulator of G-Protein Signaling (RGS) Protein Modulation of Opioid Receptor Signaling Hepler, Cellular regulation of RGS proteins: modulators and integrators of G protein signaling.
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
When it comes to signal transduction, cellular context matters. to scaffold various kinases and modulate downstream signaling pathways. can be activated by ligands and initiate signaling cascades. , sustained signaling responses from intracellular compartments can be regulated by the kinetics of signaling Compartmentalized GPCR Signaling from Intracellular Membranes.
- Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling
bound to these interaction partners available today do not reveal a clear conformational basis for signaling
Other Pages (23)
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis promotes CD8+ T cell dysfunction and immunotherapy failure. Joshua Chiou , Sanju Sinha , Marin Matic , Francesco Raimondi , Thomas S Hoang , Rebecca Berdeaux , Dario A A Vignali , Ramiro Iglesias-Bartolome , Hannah Carter , Eytan Ruppin , Jill P Mesirov , J Silvio Gutkind
- Unveiling Non-Canonical Functions for Gαq Signaling Pathways
Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling During this period and her doctoral thesis, she has deepened the regulatory mechanisms of GPCR signaling characterization of proteins that act at the level of G proteins and which are part of a multimolecular signaling complex (AGS, de “Activators of G-protein signaling). Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy
- Biochemical Mechanisms Underlying Location Bias in GPCR Signaling
Sponsors GPCR Retreat Program < Back to schedule Biochemical Mechanisms Underlying Location Bias in GPCR Signaling His lab is also interested in identifying novel signal transduction mechanisms of GPCRs, such as the