This Week’s Highlights: G protein-coupled receptor (GPCR) pharmacogenomics Miles D Thompson , David Reiner-Link , Alessandro Berghella , Brinda K Rana , G Enrico Rovati , Valerie Capra , Caroline M Gorvin Direct line to the Dr. GPCR community members Join the GPCR fan club and geek out with fellows!

January 2022 "G-protein-coupled receptors’ star has been on the rise in biotech in recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range of health conditions, from cancer and genetic disorders to inflammation and metabolic imbalances. Among those hitching their wagons to that star are Verily and Sosei Heptares, which have struck a research agreement to discover new GPCR targets that’ll fuel the development of potential drug candidates. The financial details of the strategic collaboration weren’t released, but Sosei Heptares’ past two team-ups in GPCR-based drug discovery have clocked in at $1 billion—with Genentech—and, just last November, $2.6 billion in a partnership with Neurocrine." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 ADGRL3 genomic variation implicated in neurogenesis and ADHD links functional effects to found that nsSNPs rs35106420, rs61747658, and rs734644, previously reported to be associated and in linkage GIP has been linked to the pathogenesis of diabetes mellitus, and our analyses suggest a potential link

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways Besides, high GPER expression was significantly linked to the worse survival in patients with lymph node Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

June 2022 "June 15, 2022 06:30 AM EDT - In 2016, Abbie Celniker was promoted to partner at Third Rock Ventures as the firm raised just over $600 million for its fourth fund. Since then, Celniker has helped usher in an additional fund and headed a few startups as interim CEO. Coming on its 15th year, Third Rock Ventures announced its sixth fund today — and largest one by far — at a whopping $1.1 billion. Adding it all up, Third Rock has raised $3.8 billion since its inception. That money has gone to some 60 biotechs, much of it as early funding." Read more at the source #DrGPCR #GPCR #IndustryNews

This week's highlight includes congrats to: David A Cooper, David Minh, et al., for their research on Classified GPCR News from April 1st to 7th, 2024 GPCR Activation and Signaling GPRASP1 loss-of-function links

Nguyen ,  Ziaurrehman Tanoli ,  Saad Hassan , Umut Onur Özcan ,   Jimmy Caroli ,   Albert J Kooistra ,   David Taracena Herrera , Søren N Andreassen ,   Jimmy Caroli ,   Albert J Kooistra , Gáspár Pándy-Szekeres ,   David Direct line to the Dr.

David Gloriam and Dr. Albert Kooistra.

David Gloriam and his team present GproteinDb in 2024 Are you looking to hire? adhesion GPCR dissociation GPCR Activation and Signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism The mechanism of Gαq regulation of PLCβ3-catalyzed PIP2 hydrolysis GPCR Binders

David Gloriam , Dr.

reveals unexpected differences in downstream pathway activation Chiara D Mancinelli, Joshua Levitz, David Novartis continues to deliver strong sales growth and core margin expansion in Q2; raises FY 2024 bottom-line

José Labandeira-García , Rafael Franco Endomembrane GPCR signaling: 15 years on, the quest continues Davide Direct line to the Dr.

spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos, Peter Gmeiner, Davide

Lukas Grätz, David Gloriam, and Gunnar Schulte’s research on Unveiling pathway selectivity in Frizzleds

Using shRNA knockdown and CRISPR/Cas9 knockout cell lines, as well as mouse models, we confirmed the that orchestrate P-gp expression and highlight unappreciated connections between multiple pathways linked

Burger , Arthur Christopoulos , David M.

Heterodimerization when Expressed Heterologously in Saccharomyces cerevisiae The beta 2 adrenergic receptor cross-linked intestinal dendritic cells Methods & Updates in GPCR Research Generation of CRISPR/Cas9 modified human iPSC line

Such effects are mediated by the suppression of gut IEL effector functions linked to the dampening of These data reposition key roles of the L cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R

that one should consider when attempting to compare functional outcomes from different studies, both linked to the specific assay mechanism and linked to its specific execution, as these may heavily impact the

Wednesday-Friday, 5th-7th October 2022 Place Evotec Campus Levi-Montalcini, Verona, Italy Downloads and Links

LINKED ARTICLES: This article is part of a themed issue on Structure Guided Pharmacology of Membrane

Together, these results link the morphogenetic effects of HH to the apico-basal distribution of SMO and

an oxysterol ligand and will facilitate the development of therapeutic approaches that target EBI2-linked

Structurally, the extensive extracellular domain, which contains the hormone-binding site and is linked

receptors: from radioligand binding to cellular signaling GPR101: Modeling a constitutively active receptor linked to X-linked acrogigantism State-dependent dynamics of extramembrane domains in the β2 -adrenergic receptor

Neural PKA signaling is regulated by afferent and peripheral efferent signals that link specific neural

These results suggest a link between receptor activation and immobilization.

2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation linked