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April 2022 Ono Enters into Collaboration Agreement with Domain Therapeutics and Université de Montréal (Strasbourg, France; CEO: Pascal Neuville; “Domain”) and Université de Montréal (Québec, Canada; “UdM

Tim De Groof! It’s not often when you get the best of both worlds - nano-bodies and #GPCRs.

the Department of Biochemistry and Molecular Medicine of the Faculty of Medicine of the Université de

August 2022 Luciferase-based GloSensor™ cAMP assay: Temperature optimization and application to cell-based In this regard, luminescence-based biosensors have revolutionized our ability to monitor GPCR signaling We found that preincubation and luminescence reading at room temperature were optimal as compared to

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case Reference Cam Sinh Lu. (2024, September 3).

factors, including ETS, c-Jun, and Fos, modulating gene expression and influencing cellular functions (Lu Lu, N., & Malemud, C. J. (2019). S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R. J. (2003).

Member Profile Antony Boucard Professor Centro de Investigación y de Estudios Avanzados del IPN (Cinvestav AB: Favorite Taco: Taco de suadero (pronounced swa-day-ro), fatty, with meat caramelized in its own fat Don’t be surprised if you find yourself singing Daddy Yankee’s “Gasolina” from the top of your lungs while executing your best perreo or Luis Enrique’s “Yo no sé mañana” while a stranger takes you floating

This Week’s Highlights: Congrats to: Our contributor, Cam Sinh Lu ,  who has just released an incredible team: Targeted Drug Design through GPCR Mutagenesis: Insights from β2AR China M Payne ,   Cam Sinh Lu

  Madelyn N Moore , Kelsey L Person , Abigail Alwin , Campbell Krusemark , Ezequiel Marron Fernandez de loss after a year, with no plateau INAUGURATION OF AELIS FARMA NEW LABORATORY at Institut Européen de reveals that CCBP2 and GPR87 are new GPCR-associated biomarkers for preeclampsia Metabolic control of Luteinizing

This Week’s Highlights: Harnessing Deep Mutational Scanning for Enhanced Drug Discovery Cam Sinh Lu

Rajagopal and their lab team study on 'Location bias: A "Hidden Variable" in GPCR pharmacology' Yao Lu

This week's highlight includes congrats to: Cam Sinh Lu, for his first Dr.

Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Yao Lu

Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter , Brian Bender , Chris De

odorant receptors, data mapper, structure similarity search and models of physiological ligand complexes Luis GPCR drugmaker Septerna amasses $288M in IPO Surrounded by AI bio giants, tiny startup Nabla Bio makes de

This week's highlight includes congrats to: Tessa de Vries, Graham Ladds, Antoinette MaassenVanDenBrink Chemically Diverse "Superscaffold" Library Enables Ligand Discovery for a Key GPCR Target Gunnar Schulte, Lukas

De novo drug design: AI algorithms can generate new molecules with desired properties, such as binding chemical space, limiting their ability to identify truly novel chemotypes”(Thomas, Smith, O’Boyle, de

First complete genome sequence of lumpy skin disease virus directly from a clinical sample in South India ended 31 December 2022 Addex Raises $5.0 Million in Equity Financing Testing the limits of SMILES-based de

Domain Therapeutics was nominated for the Trophée de l'Innovation Technologique (Technological Innovation

Therefore, matching a ligand to an orphan GPCRs, the process of de-orphanizing, is of great importance

Michel Bouvier received the title of Doctor Honoris Causa from the Université de Montpellier Domain Therapeutics

This week's highlight includes congrats to Omolade Otun, Chris de Graaf, Cherine Bechara, et al. for

., Luttrell, L. M., & Lefkowitz, R. J. (2003). Bénard, G., Ramos, A., Reguero, L., Arrabal, S., Elezgarai, I., Gerrikagoitia, I., Suarez, J., Rodríguez De

TM7 and the intracellular helix 8 move outward from the receptor core to make room for the G-protein (Lu constitutively active receptors, meaning they can signal independently of agonist (Casarosa, Bakker et al. 2001, Luker recycling of chemokines without activating G-protein pathways (Randolph-Habecker, Rahill et al. 2002, Luker

the proton-sensing GPCR, GPR65 on fibroblast-like synoviocytes contributes to inflammatory joint pain Luke

article on Profiling Immune Cell and Platelet Transcriptomes , and we want to wish her the best of luck leveraging GPCR expertise as a discovery engine - multiple partners have already signed on to the science Lundbeck

Photopharmacology GPCRs in Cardiology, Endocrinology, and Taste Rap1A Modulates Store-Operated Calcium Entry in the Lung

management, driving the obesity market toward $66 billion by 2030 and on track to become one of the most lucrative