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61 items found for "Dominic R Huxley"
- Ep 96 with R. Scott Struthers
GPCR Podcast << Back to podcast list Scott Struthers R. R. Scott Struthers on the web LinkedIn Google Scholar Crinetics Radionetics Dr.
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
with decitabine (DAC) demonstrated initial safety and efficacy in patients with relapsed/refractory (R/ R) AML. The current study aimed to identify molecular predictors of response to ONV + DAC in R/R AML patients A total of 44 R/R AML patients were treated with ONV + DAC and considered evaluable for efficacy. PLK1 inhibition with ONV in combination with DAC could be a potential therapy in R/R AML patients, particularly
- Context-dependent ciliary regulation of hedgehog pathway repression in tissue morphogenesis
bifunctional GLI transcription factors generate both GLI-activators (GLI-A) and GLI-repressors (GLI-R) The formation of GLI-A/GLI-R requires cilia. , and the ankyrin repeat protein ANKMY2 that direct cAMP/protein kinase-A signaling by cilia in GLI-R GLI-A formation only, or dual regulation of either lack of GLI-R or excess GLI-A formation. complex tissue-specific GLI-effector requirements in morphogenesis and point to tissue-specific GLI-R
- Session IV | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
in Axons Joseph Duman Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Kimberley Tolias Lab Bai1 Is A Novel Neuronal Substrate Of The Psychiatric Risk Kinase TNIK Simeon R. Mihaylov Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Flynn, Helen R.2, Sampedro-Castaneda Institute, UK 2Proteomics Science Technology Platform, The Francis Crick Institute, UK" About Simeon R. have recently also developed a strong interest in adhesion GPCRs and in particular, Bai1. " Simeon R.
- Ep 104 with Dr. Raul Gainetdinov
Raul Gainetdinov Raul R. Before SPBU, Raul R. In 2018-2020, Raul R.
- Full Agenda for Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Salinas Read More 12:00 PM Session IV AGPCRs signaling in the nervous system Joseph Duman · Simeon R. Steroid Hormone Receptors and Hearing and Balance Receptors Bill Huang Self-Cleavage of GPR110 SEA Domain and Its Impact on GAIN Domain Autoproteolysis Andrew Dates Heterogeneity of Tethered Agonist Signaling Tobias Langenhan The CELSR/ADGRC Homolog Flamingo Is Not Autoproteolytically Processed By The GAIN Domain ADGRF5/GPR116 receptor is a key regulator of lymphatic endothelial cell identity and function Simeon R.
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
ARB1 and ARB2 correlated negatively CERAD Trail Marking A and B (R ≤ -0.26, p ≤ 0.043), while CHRM3 correlated positively with Chadler Fatigue Scale (R = 0.37, p = 0.0087).
- Ep 57 with Dr. Peter Robert Banks
These roles included management of PerkinElmer’s BioPharma R&D program and Chair of the company’s Scientific
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
Here we analyze the RGS domains of 15 RGS protein family members using a novel bioinformatic tool that Riley E Perszyk , Nicholas H Harbin , Jennifer Okalova , Suneela Ramineni , Stephen F Traynelis , John R
- Ep 17 with Dr. Yamina Berchiche
Yamina Berchiche on the web D r.
- Ep 84 with Rosie Dawaliby
I have 10 years of experience in the development and management of R&D projects and teams in the field
- High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota Effects on the Immune System, and Western Diseases
Authors Quanbo Wang , Charles R Mackay Tags Gut microbiota , Western lifestyle diseases , portal vein
- Ep 95 with Chris Langmead
He also directs a collaborative neuroscience R&D program with Servier (France) and is the co-founder
- The landscape of cancer-rewired GPCR signaling axes
De Oliveira Rosa, Francesco Carli, Lauren Clubb, Lorenzo Amir Nemati Fard, Giorgos Kargas, Giuseppe R
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
Habgood , Amanda L Tatler , Katalin Susztak , Matthew Palmer , Stefan Offermanns , Neil C Henderson , R
- Dinner 1
November 2nd / 8:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Check In
November 2nd / 4:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Breakfast 1
November 3rd / 7:30 AM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Coffee Break 1
November 2nd / 2:45 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Coffee Break 5
November 4th / 9:55 AM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Welcome Remarks
November 2nd / 1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Coffee Break 4
November 3rd / 3:00 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Coffee Break 3
November 3rd / 10:25 AM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Registration
11:00 AM - 1:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Welcome Reception and Poster Session 1
November 2nd / 5:30 PM Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires
- Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease Phenotype and Neurodegeneration in zQ175 Mice
GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
. 1.09 ± 0.42, p < 0.001) and showed a positive correlation with immunostaining of protein in OSCC (r
- Regulation and role of mitochondria delta opioid receptors
GPCR Previous Event Next Event Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec Great Lakes GPCR Retreat and Club des Récepteurs à Sept Domaines Transmembranaires du Québec