Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang , Yingru Xing , Jing Wu , Dong Hu .

Authors Chulo Park , Jin-Woo Lee , Kiheon Kim , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Source

Authors Naina Gour , Hwan Mee Yong , Aishwarya Magesh , Aishwarya Atakkatan , Felipe Andrade , Stephane Lajoie , Xinzhong Dong Tags IFNγ , Mrgpra1 GPCR , NPFF , lung infection , neuropeptide FF , neutrophil

Results: We observed that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human Authors Jong Min Hong , Jin-Woo Lee , Dong-Seung Seen , Jae-Yeon Jeong , Won-Ki Huh Tags Cancer , Chemokine

nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting dual localization of GprC in A. flagrans resembles the localization of the cannabinoid receptor CB1 in humans Authors Xiaodi Hu, David S Hoffmann, Mai Wang, Lars Schuhmacher, Maria C Stroe, Birgit Schreckenberger

receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human receptor class C group 5 member A (GPRC5A) on lipopolysaccharide (LPS)-induced inflammatory response in human Authors Y H Hu , L L Shang , S H Ge Source Contribute to the GPCR News Coming soon Become a Contributor

She has done extensive work on the molecular pharmacology of opioid receptors and is currently focusing

< GPCR News < GPCRs in Oncology and Immunology Severity of neurological long-COVID symptoms correlates The pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune moderate SARS-CoV-2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID Results: The prevalence and concentrations of evaluated autoantibodes were significantly higher in Long-COVID significantly higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID

Graciela has done extensive work on the molecular pharmacology of opioid receptors, exploring their signaling

Authors Xiaoyan Ding , Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo

allows predictions of drug activity in all physiological systems, not only the system where testing is done

He works in a multidisciplinary Chemical Biology team based at the recently established US R&D hub in As part of Farooqi's team, he characterized a series of novel human genetic variants identified in several They also highlighted the need for a work-life balance and the joy of a well-done job.

Dandan Guo, Haizhen Lin, Muhammad Asad Farooq, Chenxu Jin, Li Zhang, Ying Zhou, Jie Yao, Yixin Duan, Cong

, Qiangcheng Wang , Lu Wang , Yang Yang , Min Ren , Yanlin Li , Zixu Gao , Shaoluan Zheng , Yiteng Ding

Authors Ahmad Raza , Meng-Chi Yen , Gangga Anuraga , Iram Shahzadi , Muhammad Waqar Mazhar , Hoang Dang

GPCRs in Oncology and Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human However, the impacts of gut microbe-GPCR interactions on human physiology have not been fully elucidated specifically expressed on type 1 conventional dendritic cells (cDC1s) in the lamina propria of the human Using human induced pluripotent stem cell-derived cDC1s and a monolayer human gut organoid coculture Our results highlight the role of GPCRs in tuning the human gut immune system according to local metabolic

and Immunology Receptor autoantibodies: Associations with cardiac markers, histology, and function in human Published date April 1, 2023 Abstract " Aims: A causal link between non-ischaemic heart failure (HF) and humoral

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity Published date April 4, 2024 Abstract "Efficient induction of humoral immune responses depends on orchestrated to chemoattractant receptors and plays an important role in the control of B cell migration during humoral review, we summarize the current understanding of chemoattractant receptor signaling in the context of humoral

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells Using both gene knockdown and biochemical methods, we demonstrated here that two human TIPE family members , TNFAIP8 and TIPE2 were essential for directed migration of human CD4+ T cells. Collectively, our work describes a new mechanistic paradigm for how human T cells integrate GPCR and These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and

Committee Sponsors GPCR Retreat Program < Back to schedule Genetic Deletion of Atypical VGLUT3 Rescues Huntington G-protein coupled receptors and their role in neurodegenerative disorders, including Alzheimer's and Huntington's

< GPCR News < GPCRs in Oncology and Immunology Transcriptomic analysis of human cytomegalovirus to survey indirect effects on renal transplant recipients Published date May 30, 2023 Abstract "Post-transplant human transplant (RT) patients was analyzed to seek the underlying pathobiologic pathways associated with the long-term Tags Human cytomegalovirus , Indirect effects , RNA-Seq , Renal transplantation , Transcriptome .

GPCRs in Oncology and Immunology The binding mechanism of an anti-multiple myeloma antibody to the human

< GPCR News < GPCRs in Oncology and Immunology Natural carboxyterminal truncation of human CXCL10 attenuates As a consequence of natural posttranslational modifications, human CXCL10 exhibits a high degree of structural the four endmost C-terminal amino acids, which was previously identified in supernatant of cultured human migration, second messenger signaling downstream of CXCR3, and flow cytometry of CHO cells and primary human Furthermore, CXCL10(1-73) incited significantly less primary human T lymphocyte chemotaxis in vitro and

< GPCR News < GPCRs in Oncology and Immunology NPFF stimulates human ovarian cancer cell invasion by The TaqMan probe-based RT-qPCR showed that NPFF and NPFFR2 were expressed in three human EOC cells, CaOV3

News < GPCRs in Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers in human cell lines and found that CXCR4 assembles into multimeric complexes larger than dimers in MDA-MB-231 human breast cancer cells and in HCC4006 human lung cancer cells. These results suggest that CXCR4-β2AR heteromers are present in human cancer cells and that GPCR multimerization Bhum Song , Chulo Park , Piotr Zalicki , Jae-Yeon Jeong , Won-Ki Huh , Niña G Caculitan , Adam W Smith

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune

frequent and specific expression of PRL3 in pediatric solid tumors for first-in-child use of PRL3-zumab humanized PRL3-zumab, a first-in-class humanized antibody, was administered in a dose escalation schedule in a Authors Amos Hong Pheng Loh , Min Thura , Abhishek Gupta , Sheng Hui Tan , Kelvin Kam Yew Kuan , Koon Hwee Ang , Khurshid Merchant , Kenneth Tou En Chang , Hui Yi Yon , Yong Chen , Mathew Hern Wang Cheng

Because the TA-mediated mechanism is a “one and done” mechanism that is irreversible and prevents the