cyclophosphamide regimen for the treatment of adult patients with severe, active granulomatosis polyangiitis (GPA

(1-100 μg/L) significantly altered transcriptional expressions of some neuronal Gα genes, including gpa -5, gpa-10, gpa-11, gpa-15 gsa-1, egl-30, and goa-1. Among these 7 Gα genes, only neuronal RNAi knockdown of gsa-1, gpa-10, and goa-1 affected toxicity of of GSA-1, and some neuronal GPCRs (such as DOP-2, NPR-8, DAF-37, and DCAR-1) functioned upstream of GPA and DAF-7/ TGF-β, GSA-1 functioned upstream of MPK-1/ERK MAPK, JNK-1/JNK MAPK, and DBL-1/TGF-β, and GPA

indicated for the treatment of adult patients with severe, active granulomatosis with polyangiitis (GPA

polyps , Chronic spontaneous urticaria , Colony stimulating factor 2 , DRG , Dorsal root ganglion , EGPA