Authors Roberta Goncalves Anversa, Maiya L Barron, Leigh C Walker, Andrew J Lawrence Source Contribute

< GPCR News < GPCRs in Oncology and Immunology Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation Published date April 27, 2023 Abstract " Alveolar development and repair Transforming growth factor-β (TGFβ) is essential for alveologenesis and lung repair, and the G protein Mice with constitutive Gαq/11 gene deletion exhibited abnormal alveolar development, with suppressed Tags Alveologenesis , Cyclical mechanical stretch , GPCR , Gαq/11 , Lung development , TGFβ .

Organoid culture was used to assess the stemness and self-renewal capacity of alveolar epithelial type Organoid culture assays showed slower alveolar organoid formation, fewer alveolar organoids, and impaired