Search Results
17 items found for "Elihu H Estey"
- A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...
August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology
- Nanobodies: New Dimensions in GPCR Signaling Research
., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology. D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P.
- APEX2/AUR Biosensor: A Powerful Tool for Protein Interaction and Trafficking
peroxidase enzyme that catalyzes the oxidation of specific substrates in the presence of hydrogen peroxide (H When AUR is oxidized by APEX2 in the presence of H 2 O 2 , it produces a fluorescent product that can
- From DNA day to GPCR genomics
., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. G., & Schiöth, H. B. (2003). M., Pérez-Hernández, G., Batebi, H., Gao, Y., Eskici, G., Seven, A.
- Bursicon receptor gene HLGR2 as a potential RNA interference target for control of the fall ...
Unlike LGR2 in other insect species, HLGR2 was found to play a crucial role in the control of H. cunea Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.
- Odorant receptors – a bit of smell for drug discovery
than 60 ORs in the testis and only a few ORs in the liver (Flegel C. et al. 2013; Maßberg D. and Hatt H. although there are highly increased in prostate tissue, especially in prostate cancer (Maßberg D. and Hatt H. olfactory-specific chaperones to be correctly targeted to the surface of heterologous cells (Maßberg D. and Hatt H.
- Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery
References Eishingdrelo, H., & Kongsamut, S. (2013). Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R.
- To probe the activation mechanism of the Delta opioid receptor by an agonist ADL5859 started from...
will facilitate further development of therapeutic agents targeting the DOR.Communicated by Ramaswamy H.
- Decoding β-Arrestins: from Structure to function
F et al. 2021, Chen, H. et al. 2022). H., & Lee, J. H. 2020, Casiraghi, M. et al. 2019), double electron-electron resonance (DEER) spectroscopy for high-resolution
- Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors
expression, restoration to ≥57% of WT levels was achieved for 6 by treatment with 1 µM CAN1404 for 24 h,
- Do You Believe AI Could Accelerate Drug Discovery?
Of 161 molecules tested, 42 substituted more than 50% of [³H]-LSD at 10 μM, achieving a 26% hit rate.
- An overview of the compartmentalized GPCR Signaling: Relevance and Implications
Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy Z., Wilderman, A., Katakia, T., McCann, T., Yokouchi, H., Zhang, L., Corriden, R., Liu, D., Feigin, M
- Unlocking Cell's Secrets: Spontaneous β-Arrestin-Membrane Preassociation Drives Receptor-Activation
H., Heydenreich, F. M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K.
- Overview of adhesion GPCRs self-activation
., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z., Huang, Z., & He, Y. (2022).
- Ode to GPCRs
George H. Edmond H.
- Unlocking the Therapeutic Potential of Previously Undruggable GPCRs
of a small protein GPCR ligand using new peptide chemistry technology and rational design Gaertner, H.