kinases (GRKs) and subsequent recruitment of β-arrestins, resulting in receptor internalization into endosomes has been extended by discovering that some internalized GPCRs continue to signal via G proteins from endosomes the parathyroid hormone (PTH) type 1 receptor (PTHR), which engages on sustained cAMP signaling from endosomes This mini-review discusses recent insights into the mechanisms of PTHR endosomal signaling and its physiological

protein complex in neurotransmitter release has been well characterized, the mechanisms that modulate the delivery molecular players, including SNARE proteins; here, SNARE proteins play a role in the fusion of recycling endosomes

GPCRs, G proteins, and arrestins on endosomal membranes3,4. Furthermore, targeting GPCRs in specific cellular compartments requires precise delivery mechanisms to This may involve the development of specialized delivery vehicles, such as nanoparticles or liposomes expressed in cellular compartments require innovative approaches to overcome barriers related to stability, delivery Towards a molecular understanding of endosomal trafficking by Retromer and Retriever.

Moreover, endosomal delivery of GPCR ligands by nanoparticles can precisely initiate sustained endosomal This significantly enhances the potency of nanoparticle delivery systems. delivery of GPCR ligands by nanoparticles can magnify endosomal signalling. Jiang , Yuke Li , Xiujuan Fu , Yue Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G protein-coupled receptors (GPCRs) , Molecular targeting , Nanoparticles , Signal

< GPCR News < GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and However, the regulation mechanisms that determine exosome contents during exosome biogenesis remain poorly Here, we find that GPR143, an atypical GPCR, controls the endosomal sorting complex required for the transport (ESCRT)-dependent exosome biogenesis pathway. protein sorting , exosome biogenesis , melanoma , metastasis .

She recently led a project that demonstrated the GPCR kinases (GRKs) can translocate to endosomes, and