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Moreover, endosomal delivery of GPCR ligands by nanoparticles can precisely initiate sustained endosomal This significantly enhances the potency of nanoparticle delivery systems. delivery of GPCR ligands by nanoparticles can magnify endosomal signalling. Jiang , Yuke Li , Xiujuan Fu , Yue Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G protein-coupled receptors (GPCRs) , Molecular targeting , Nanoparticles , Signal

< GPCR News < GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and However, the regulation mechanisms that determine exosome contents during exosome biogenesis remain poorly Here, we find that GPR143, an atypical GPCR, controls the endosomal sorting complex required for the transport (ESCRT)-dependent exosome biogenesis pathway. protein sorting , exosome biogenesis , melanoma , metastasis .

She recently led a project that demonstrated the GPCR kinases (GRKs) can translocate to endosomes, and

of the adaptor protein, β-arrestin, is a tag for receptor internalization and formation of signaling endosomes

signaling outputs of biased agonists, and demonstrating the ligand specificity behind GRK recruitment to endosomes

finding that both β-arrestin and G protein can simultaneously bind to some GPCRs when signaling in endosomes

< GPCR News < GPCRs in Oncology and Immunology Delivery of US28 by incoming HCMV particles rapidly attenuates

GPCRs expressed in cancer biopsies, matched with personalised GPCR-targeted nanomedicines, for the delivery Ricciardelli, Martin K Oehler, Anton Blencowe, Sanjay Garg, Katherine Pillman, Hugo Albrecht Tags Drug delivery

More significantly, intratumoral delivery of UCA1-specific siRNAs inhibits the growth of cisplatin-refractory

treatment of GBM is challenging due to the presence of the blood-brain barrier (BBB), which hinders drug delivery

Apostichopus japonicus: Ultrastructure and transcriptional profile Read More December 1, 2024 Intranasal delivery