Search Results
22 items found for "Enrico Rovati"
- Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients
Afterward, Gene Ontology (GO) and pathway enrichment analyses were conducted to determine the enriched KEGG pathway analysis revealed the enrichment of DEGs in IL18 signaling, AGE-RAGE signaling pathway in The expression levels of six genes involved in enriched pathways including F3, PTX3, ADRA2B, GNG11, GP9
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
results showed that the downregulated differentially expressed genes (DEGs) in the T3-SCI group were enriched Traf6, Akap8, Gfer, Cxcl10, Tnfaip3, Icam1, Fcgr2b, Ager, Dusp10, and Mapkapk2) were significantly enriched the downregulated genes (hub genes: Grm4, Nmu, P2ry12, rt1-bb1, Oprm1, Zfhx2, Gpr83, and Chrm2) were enriched The upregulated genes in the adrenal glands (hub genes: Ciart, per2, per3, cry1, and cry2) were enriched IL7r, rt1-bb, rt1-bb1, rt1-da, rt1-ba, cd74, cxcr3, vcam1, ccl5, bin1, and IL8) were significantly enriched
- Investigating isoform switching in RHBDF2 and its role in neoplastic growth in breast cancer
Furthermore, interacting partners were found via correlation and enriched to explain their antagonistic Neither EGFR nor ERAD was found enriched. and the proteasomal degradation pathway and cytoplasmic ribosomal protein pathways were significantly enriched
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were Functional enrichment analysis revealed the promising therapeutic effects of these targets on GPCRs-related
- Single cell G-protein coupled receptor profiling of Transcription factor 21 expressing activated kidney fibroblasts
Transcription factor 21 (Tcf21)+ cells that expressed 2 or 3 of Postn, Acta2 and Pdgfra were highly enriched Conclusion and implications: Tcf21 is a marker of kidney fibroblasts that are enriched for fibrogenic
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
expressed (DE) genes between experimental groups were characterized based on RNA-seq and Gene Ontology (GO) enrichment GO analysis revealed seven significantly enriched biological processes affected by PR and associated
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
Wilcoxon sign-rank test, logistic regression, Kaplan-Meier method, Cox regression analysis, Gene set enrichment PI3K-Akt signaling pathway, and Focal Adhesion-PI3K-Akt-mTOR-signaling pathway were differentially enriched
- Comparative analysis of the occupancy of Histone H3 Lysine 4 methylation in the cells treated with TGFβ and Interferonγ
DAVID Functional enrichment analysis in the TGFβ and IFNγ dataset revealed association of genes with
- Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery
Here, we demonstrate the feasibility of enriching the populations of discrete states via conformation-biased
- Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration
Harvested cellular proteins were digested and phosphopeptides were enriched by immobilized titanium (
- Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors
the mutations across the protein domains did not differ significantly in the two datasets, a mutation enrichment
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
singe-cell RNA-sequencing datasets from CD8+ T cells covering 19 distinct cancer types and identified an enrichment
- C5aR2 receptor: The genomic twin of the flamboyant C5aR1
modeling and the 1.5-μs molecular dynamics data presented in the current study are expected to further enrich
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
immunological characteristics of the high- and low-risk groups were analyzed using single-sample gene set enrichment
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
Role of GPR97 is indispensable and this adhesion receptor may affect immune cell enrichment and function
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
signature, predictive of response to ONV + DAC, was derived from the leading-edge genes of gene set enrichment
- The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor
Lymphocytes enriched from Gpr141 -/- mice immunized with myelin oligodendrocyte glycoprotein 35-55 produced
- RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
Furthermore, Transcriptome sequencing was performed to show enrichment genes and pathways.
- GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis
Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption
- Regulator of G protein signaling protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice
differentially expressed genes (DEGs) in an acute lung injury (ALI) model were identified, and functional enrichment
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
Differential expression and functional enrichment analyses were performed; protein-protein interaction
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
representative of breast carcinomas with lower versus higher invasive potential reveal differential enrichment