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75 items found for "Filippo Prencipe"
- Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology
Beth is also the hiring manager for their open Principal Scientist, In Vitro Pharmacology role posted Mark: “So, what are the qualities of the perfect candidate for the Principal Scientist role?”
- Precise druggability of the PTH type 1 receptor
This study provides a computational pipeline to detect precise druggable sites and identify allosteric
- 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024
We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you Here’s the refreshed schedule: Principles of Pharmacology I October 3, 10, 17, 24 Principles of Pharmacology Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .
- GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...
GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors. In the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term GPCR activities associated with the regulation of protein expression patterns, cellular stress responses and DNA integrity management. The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control complex cellular activities implicates them as key controllers of the functional balance between health and disease. A greater understanding of this function of GPCRs is likely to significantly augment our ability to further employ these proteins in a multitude of diseases. Read full article
- 📰 GPCR Weekly News, July 1 to 7, 2024
Here’s a sneak peek at what you can expect: Principles of Pharmacology in Drug Discovery I - Techniques Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal
- GPCR Updates: Celebrating Breakthroughs, New Course Launches Soon, and Exclusive Discounts! | Aug 26 - Sep 1, 2024
Every Thursday at 10 AM EST: Principles of Pharmacology I October 3, 10, 17, 24 (four sessions) Explore Principles of Pharmacology II October 31, November 7, 14, 21, December 5 (five sessions) (we skipped The Principles of Pharmacology I & II BUNDLE is your golden ticket to mastering the field. -3, 2024, in Boston and online) gathers top researchers to explore the latest advances in designing precise
- 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!
Dear GPCR Enthusiasts , Get ready for an exciting learning experience with our newly updated Principles New Course Dates: Principles of Pharmacology I : October 3, 10, 17, 24 (four sessions) Principles sessions) Courses Highlights Act Fast: Don’t miss this incredible opportunity to immerse yourself in the Principles
- 📰 GPCR Weekly News, May 1 to 7, 2023
board Crinetics Pharmaceuticals First Quarter 2023 Earnings: Revenues Beat Expectations, EPS Lags “As Precision GPCR Jobs Vice President, Medical Affairs Associate Scientist - Technology Senior Research Scientist/Principal
- Dr. Juan José Fung - Dr. GPCR Podcast
Juan Jose Fung, Principal Scientist, at GPCR Therapeutics.
- 📰 GPCR Weekly News, April 24 to 30, 2023
A visual opsin from jellyfish enables precise temporal control of G protein signalling. October 25 - 27, 2023) GPCR Jobs NEW Associate Scientist - Technology NEW Senior Research Scientist/Principal
- Michel Bouvier appointed Knight of the Ordre national du Québec
2022 "Published on juin 22, 2022 On June 22, 2022, Michel Bouvier , Chief Executive Officer of IRIC, Principal
- Posttranslational modifications in GPCR internalization
for the receptor internalization, the mechanism of physiology/pathology and novel drug targets for precision will offer new insights into the regulatory mechanism of GPCR signaling and novel drug targets for precision
- Tracking receptor motions at the plasma membrane reveals distinct effects of ligands on CCR5...
issue in living cells for the CC chemokine receptor 5 (CCR5), a major receptor in inflammation and the principal
- 📰 GPCR Weekly News, May 20 to 26, 2024
GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal
- Orion and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical ...
and Peptilogics are pursuing AI-driven drug discovery to explore new functional chemical space and precision-engineer
- 📰 GPCR Weekly News, April 22 to 28, 2024
GPCR Matchmaking Did you check out our first job opportunity spotlight for a Principal Scientist In Vitro Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Post Doctoral Fellow Postdoc Position Principal
- 📰 GPCR Weekly News, April 15 to 21, 2024
GPCR Matchmaking Did you check out our first job opportunity spotlight for a Principal Scientist In , 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Postdoc Position Principal
- Targeted Activation of G-Protein Coupled Receptor-Mediated Ca 2+ Signaling Drives Enhanced Cartilage
activation of endogenous Ca2+ signaling transducers; however, such approaches can lack specificity and/or precision Synthetic signaling platforms permitting precise and selective Ca2+ signal transduction can improve dissection We previously demonstrated hM3Dq's ability to precisely and synthetically initiate robust [Ca2+]i transients
- Transformative GPCR Insights: Unleash New Horizons in Science | Sep 9 - 15, 2024
🚨 Hurry to reserve your spot for the Principles of Pharmacology I & II BUNDLE before the Early Every Thursday at 10 AM EST: Principles of Pharmacology I Dates: October 3, 10, 17, 24 (four sessions Registration deadline: September 27, 2024 Principles of Pharmacology II Dates: October 31, November
- Unlock the Future of GPCR Science: Breakthroughs and Courses Await | Sep 2 - Sep 8, 2024
Every Thursday at 10 AM EST: Principles of Pharmacology I October 3, 10, 17, 24 (four sessions) Topics Principles of Pharmacology II October 31, November 7, 14, 21, December 5 (five sessions) (we skipped The Principles of Pharmacology I & II BUNDLE is your key to mastering the field.
- Illuminating GPCR Research: FRET and BRET-Based Sensors Shed Light on Cellular Signaling
FRET and BRET sensors operate on the principle of energy transfer between a fluorescent or luminescent cellular processes, but also hold immense promise in accelerating drug discovery efforts by enabling the precise
- 📰 GPCR Weekly News, May 13 to 19, 2024
And don’t miss our job opportunity spotlight for a Principal Scientist in In Vitro Pharmacology! July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal
- Do You Believe AI Could Accelerate Drug Discovery?
This validates AF2's potential in enhancing drug discovery precision and efficiency. spark innovation in automated screening and large-scale data analysis, paving the way for a new era in precision
- Structural view of G protein-coupled receptor signaling in the retinal rod outer segment
tomography (cryo-ET) data on the ROS with structural knowledge on individual proteins to define the precise
- Exploring the Breakthroughs in GPCR Research
Course Schedule and Details Every Thursday at 10 am EST Principles of Pharmacology in Drug Discovery Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate
- Single-molecule counting applied to the study of GPCR oligomerization
October 2022 "Single-molecule counting techniques enable a precise determination of the intracellular
- The expression and clinical significance of GPR39 in colon cancer
Background: Colorectal cancer is the third most common cancer and requires more prognostic biomarkers for precise
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Many such biosensors are based on the principle of Förster resonance energy transfer (FRET), and we have