GPCR Summit 2022 is less than a month away!

neuron morphogenesis and shapes chemo- and mechanosensation-dependent behavior in C. elegans via a trans Latrophilins in the nematode Caenorhabditis elegans can also function independently of their seven-transmembrane domain and C terminus (trans function). Here, we show that Latrophilin-1 acts in trans to mediate morphogenesis of sensory structures in the This trans function is physiologically relevant in copulation behavior.

August 2022 "Opioid receptors (ORs) represent one of the most significant groups of G-protein coupled receptor (GPCR) drug targets and also act as prototypical models for GPCR function. In a constant effort to develop drugs with less side effects, and tools to explore the ORs nature and function, various (poly)pharmacological ligand design approaches have been performed. That is, besides classical ligands, a great number of bivalent ligands (i. e. aiming on two distinct OR subtypes), univalent heteromer-selective ligands and bitopic and allosteric ligands have been synthesized for the ORs. The scope of our review is to present the most important of the aforementioned ligands, highlight their properties and exhibit the current state-of-the-art pallet of promising drug candidates or useful molecular tools for the ORs." Read more at the source #DrGPCR #GPCR #IndustryNews

Authors Florian Tran , Danielle M M Harris , Alena Scharmacher , Hanna Graßhoff , Kristina Sterner ,

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune this, we developed and validated a sensitive, specific, semi-quantitative method for detecting these transcripts We have used the method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and Authors Arne Hansen, Daniel Martin, Florian Langer, Kathleen Harrison, John Kehrl, Claudia Cicala, Elena

10:00 AM Student Flash Presentations Health and Disease, Metabolism, Nervous System, Proteomics and Transcriptomics 00 PM Session V Structural mechanisms of AGPCR signaling and function Fabian Pohl · Sumit Bandekar · Florian Characterizing hADGRE5/CD97 Activation and Signaling: A Mechanical Stimulation BRET-Based Approach (MS-BRET) Florian Kordon Conformational And Functional Coupling Between Extracellular and Transmembrane Regions of a Holo-Adhesion for Brain Cancer Therapy Hailey Steichen Identification of Differentially Expressed Gpr116 (Adgrf5) Transcript