September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal caused by MRGPRB2 activation were blocked by U73122 (PLC blocker) or 2-APB (IP3 blocker) or synta66 (ORAI Our results indicated the involvement of the PLC-IP3-ORAI signaling pathway and CACCS in MRGPRB2-mediated

Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury "Traumatic brain injury (TBI) is a leading cause of disability in the US.

agonist determined by serial femtosecond crystallography (SFX) at the Pohang Accelerator Laboratory X-Ray

accordance with our findings demonstrating the prevalence of 5-HT2A–TrkB heteroreceptor complexes in these brain especially the striatum, demonstrating that the balance between TrkB and 5-HT2A may shift in certain brain heterodimerization and suggest that the regulated expression of 5-HT2A and TrkB is a molecular mechanism for the brain-region-specific

parallel pathways independently relay innate threat signals from different sensory modalities to multiple brain innate threat cues are integrated and conveyed from each sensory modality to the amygdala, a critical brain parvocellular subparafascicular nucleus in the thalamus and external lateral parabrachial nucleus in the brainstem

September 2022 "Glutamate is the primary excitatory neurotransmitter in the brain and plays critical orthosteric and allosteric ligands acting on either mGluR2, mGluR3 or both for the management of these brain

September 2022 Cannabinoid type-2 receptors: An emerging target for regulating schizophrenia-relevant brain electrophysiological studies, indicate that CB2 receptors are expressed in specific dopaminergic and glutamatergic brain

discovery programs in key therapeutic areas Kallyope, pioneers in drug discovery involving the gut-brain biopharmaceutical company, and New York City-based Kallyope, pioneers in drug discovery involving the gut-brain

Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumour in adults. Despite this, the prognosis remains poor, with an impacted quality of life during treatment coupled with brain

functions distinct from odor perception, and may contribute to the pathogenesis of disorders including brain Glioma is the most common adult malignant brain tumor and requires novel therapeutic strategies to improve Here, we outlined the expression of brain ORs and investigated OR expression levels in glioma.

by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the brain

Exclusive access to private groups  Over 30 recorded talks from Symposia - that's a lot of brain food To Design Novel GPCR- Targeted Antibody Therapeutics Using Generative AI Zombie Fungi Hijack Hosts’ Brains punctata GPCRs in Neuroscience Neuron specific quantitation of Gαolf expression and signaling in murine brain

Alterations in the expression and/or activity of brain G-protein-coupled receptors (GPCRs) such as dopamine Since studies have indicated that flavonoids can target brain GPCRs and provide neuroprotection via inhibition

September 2022 "For decades, glioblastoma multiforme (GBM), a type of the most lethal brain tumor, has

functional role of the astrocytic Gi pathway is not clear, as the literature is conflicting depending on the brain between enhanced calcium transients and the inflammatory phenotype of astrocytes observed in the inflamed brain

fundraising gives us the means to achieve our ambitions: to become a leading player in the field of brain

in high-resolution techniques to investigate peptidergic transmission and expression throughout the brain

Crinetics hires people with big brains and small egos.”

This compound has vastly reduced brain penetration and is devoid of significant off-target liability.

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

The adenosine A1 and A2A receptors are expressed in the human brain and have a proposed involvement in

In other brain regions, astrocytes sense diverse neurotransmitters and neuromodulators and, in turn,

Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic

mechanisms N. meningitidis employ to manipulate the immune system, translocate the mucosal and blood-brain

TGR5 is widely distributed in the brain, lung, heart, liver, spleen, pancreas, kidney, stomach, jejunum

accumbens shell and structures in the prefrontal cortex and amygdala, which were previously linked to the brain

immune system, including neutrophils, monocytes, and macrophages in the periphery and microglia in the brain

October 2022 "Understanding the dopaminergic system is a priority in neurobiology and neuropharmacology. Dopamine receptors are involved in the modulation of fundamental physiological functions, and dysregulation of dopaminergic transmission is associated with major neurological disorders. However, the available tools to dissect the endogenous dopaminergic circuits have limited specificity, reversibility, resolution, or require genetic manipulation. Here, we introduce azodopa, a novel photoswitchable ligand that enables reversible spatiotemporal control of dopaminergic transmission. We demonstrate that azodopa activates D1-like receptors in vitro in a light-dependent manner. Moreover, it enables reversibly photocontrolling zebrafish motility on a timescale of seconds and allows separating the retinal component of dopaminergic neurotransmission. Azodopa increases the overall neural activity in the cortex of anesthetized mice and displays illumination-dependent activity in individual cells. Azodopa is the first photoswitchable dopamine agonist with demonstrated efficacy in wild-type animals and opens the way to remotely controlling dopaminergic neurotransmission for fundamental and therapeutic purposes." Read more at the source #DrGPCR #GPCR #IndustryNews