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841 items found for "G-protein coupled receptor signaling"

Posts (468)

  • G protein-coupled receptor signaling: transducers and effectors

    October 2022 "G protein-coupled receptors (GPCRs) are of considerable interest due to their importance to initiate downstream effector signaling. This review aims to explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system of the three most important GPCR signaling effectors: heterotrimeric G proteins is increasing appreciation for the elegance of the regulatory mechanisms that mediate intracellular signaling

  • Pepducin-mediated G Protein-Coupled Receptor Signaling in the Cardiovascular System

    October 2022 "Pepducins are small-lipidated peptides designed from the intracellular loops of G protein-coupled receptors (GPCRs) that act in an allosteric manner to modulate the activity of GPCRs. This review will focus in particular on pepducins designed from protease-activated receptors, C-X-C motif chemokine receptors, formyl peptide receptors, and the β2-adrenergic receptor. , signaling, pathophysiologic consequences, and therapeutic potential for each pepducin class."

  • Structural view of G protein-coupled receptor signaling in the retinal rod outer segment

    October 2022 "Visual phototransduction is the most extensively studied G protein-coupled receptor (GPCR ) signaling pathway because of its quantifiable stimulus, non-redundancy of genes, and immense importance published cryo-electron tomography (cryo-ET) data on the ROS with structural knowledge on individual proteins maintaining the spacing between ROS discs, suggesting a plausible mechanism by which intrinsic optical signals

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Other Pages (373)

  • Ep 156 with Dr. Justin English

    developing and innovating technologies to solve broad questions in pharmacology, with a specific focus on G-protein coupled receptor signaling and biology."

  • Ep 70 with Dr. Stephen Ferguson

    Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking , and signaling. His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease.

  • Ep 69 with Dr. Stephen Ferguson

    Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking , and signaling. His research career has focused on the investigation of the regulation of G protein-coupled receptors signaling mechanisms in health and disease.

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