< GPCR News < GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology Published date July 28, 2023 Abstract "G protein-coupled receptors (GPCRs), as the largest family of membrane receptors, actively modulate plasma membrane and endosomal signalling. binding and mediate receptor-dependent endocytosis of nanoparticles. protein-coupled receptors (GPCRs) , Molecular targeting , Nanoparticles , Signal transduction Source

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune

< GPCR News < GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor cells identify pleiotropic and cell type-specific functions Published date November 1, 2022 Abstract G-protein coupled receptor kinases (GRKs) participate in the regulation of chemokine receptors by mediating receptor They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their Authors Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets Published date September 27, 2024 Abstract "G-protein coupled receptors (GPCRs) On average, the white cells studied expressed 160 receptor mRNAs (range, 123-206). Some, but far from all, of the receptors we found have been detected earlier. We believe our data should stimulate studies of receptor function and contribute to drug development.

< GPCR News < GPCRs in Oncology and Immunology Signaling by Neutrophil G Protein-Coupled Receptors that Neutrophils, which express many receptors that are members of the large family of G protein-coupled receptors synthesis and recognized by formyl peptide receptors (FPRs) and free fatty acids recognized by free fatty acid receptors (FFARs) regulate neutrophil functions. The receptors have signaling and functional similarities, although there are also important differences

GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors Published date December 1, 2022 Abstract G Protein-coupled receptors (GPCRs While the location of the mutations across the protein domains did not differ significantly in the two Our approach was confirmed by re-discovery of established cancer targets such as the LPA and mGlu receptor families, but also discovered novel GPCRs which had not been linked to cancer before such as the P2Y Receptor

< GPCR News < GPCRs in Oncology and Immunology Identification of a G-protein coupled receptor-related G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic model , epithelial Source

< GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor Published date April 29, 2024 Abstract "G protein-coupled receptors (GPCRs) regulate many cellular processes in response to various stimuli, including light, Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses Authors Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled

Marc G. Caron at Duke University (1994-1997), where he and his colleagues investigated the role of G protein-coupled receptor kinases and beta-arrestin in regulating G protein-coupled receptor endocytosis, trafficking His research career has focused on the investigation of the regulation of G protein-coupled receptors Institutes of Health Research (CIHR) for his research investigating the role of metabotropic glutamate receptor

polyangiitis , European Medicines Agency , FDA , FcεRIα , FeNO , Fractional exhaled nitric oxide , G-protein-coupled -31 receptor A , Interleukin-33 receptor , Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 , MRGPRX1 , Mas-related family of G protein-coupled receptor 11 , Mas-related family of G protein-coupled receptor X1 , Mas-related family of G-protein-coupled receptor 3 , Mas-related family of G-protein-coupled receptors , Mitogen-activated protein kinase ,

Protein-Coupled Receptor GPR56 Is an Inhibitory Checkpoint for NK Cell Migration Read More September 12, 2024 Loss of cardiomyocyte-specific Adhesion G Protein Coupled Receptor G1 (ADGRG1/GPR56) promotes pressure overload-induced heart failure Read More September 5, 2024 The G protein-coupled receptor ADGRG6 G Proteins in Two Lepidopteran Species Read More October 1, 2024 Target-based discovery of antagonists of the tick (Rhipicephalus microplus) kinin receptor identifies small molecules that inhibit midgut

< GPCR News < GPCRs in Oncology and Immunology Olfactory Receptors and Tumorigenesis: Implications for Diagnosis and Targeted Therapy Published date October 4, 2024 Abstract "Olfactory receptors (ORs) are a class of G protein-coupled receptors (GPCR) widely distributed in olfactory sensory neurons and various Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and Authors Yi Tang, Ye Tian, Chun-Xia Zhang, Guo-Tai Wang Tags G Protein-coupled receptors , Olfactory receptors

Published date May 13, 2023 Abstract "The adipokine chemerin is the endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled receptors (GPCR). Stable receptor-ligand interactions are highly relevant for its different physiological effects, e. g Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding

< GPCR News < GPCRs in Oncology and Immunology Orphan receptor GPR50 attenuates inflammation and insulin G protein-coupled receptors (GPCRs) are involved in endocrine and metabolic processes as well as many GPR50 (G protein-coupled receptor 50) is an orphan GPCR that shares the highest sequence homology with melatonin receptors. deficiency increased inflammation in 3T3-L1 cells and induced the phosphorylation of AKT and insulin receptor

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding

York) in 1990 and 1992, working with Ravi Iyengar on regulation/desensitization of the liver glucagon receptor His initial project to identify and clone taste receptors was unsuccessful, but led to the identification For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding

Specifically, I am interested in understanding dysregulated G-protein coupled receptor (GPCR) signaling In this study, I discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. More recently, I have shifted my focus to identifying allosteric modulators of host G-protein-coupled receptors (GPCRs) that contribute to cardio-metabolic disorders.

Friday, November 3rd / 2:10 PM About Karim Ibrahim "A postdoctoral researcher, interested in studying G-protein coupled receptors and their role in neurodegenerative disorders, including Alzheimer's and Huntington's

perception, transmission, and feedback are all rely on a signal network that constituted by membrane receptors Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting These studies highlight a crucial G protein signaling pathway for cell communication that is mediated Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication , G protein-coupled receptor , Mycotoxin , Oxylipin , Second messenger Source Contribute to the GPCR News

research was focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr

protein-coupled receptor latrophilin-3 (ADGRL3) modulation of dopaminergic neurotransmission Nicole Perry-Hauser and glutamate receptors and are responsible for the formation and stability of the vast majority of Several adhesion G protein-coupled receptors (aGPCRs) have recently been shown to play critical roles Dimitris Placantonakis on the web Placantonakis Lab Google Scholar LinkedIn Adhesion G protein-coupled protein-coupled receptor (aGPCR) biology.

trabecular bone but not fibrosis in a murine model with fibrotic bone Published date May 1, 2024 Abstract "G protein-coupled receptors (GPCRs) mediate a wide spectrum of physiological functions, including the development mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic cell lineages using an engineered receptor pathway inhibition , fibrotic bone disease , fibrous dysplasia (FD) , osteoblasts , trabecular bone , G-protein coupled receptor signaling , GPCR , Gnas , Gsα .

the Institute of Pharmacology of Sherbrooke and is an emerging leader in the structural biology of G Protein-Coupled Receptors and passive transporters.

protein-coupled receptors in mouse tissues. protein-coupled receptors in mouse tissues. research was focused on investigating the cellular effects of missense lung cancer-mutations in the G-protein-coupled receptor Autoproteolysis-Inducing (GAIN) domain of Latrophilin 3 receptor under the mentorship of Dr Proteolytic Processing, Trafficking And Signalling Pal Kasturi Abstract "ADGRG6 is a member of the adhesion G-protein-coupled

research fellow endeavoring to build a productive, independent scientific research career in adhesion G protein-coupled receptor (aGPCR) biology. research interests involve resolving signaling pathways downstream of aGPCRs and establishing how/if these receptors

Domain Autoproteolysis Andrew Dates Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled protein coupled receptor B1 (ADGRB1/BAI1) generated from an alternative promoter in intron 17 Emmanouil Protein-Coupled Receptors Beatriz Blanco Redondo Uncovering the signaling pathway of the ADGRA homolog protein-coupled receptor latrophilin-3 (ADGRL3) modulation of dopaminergic neurotransmission Anastasia protein-coupled receptors in mouse tissues.