Depletion of GPR108 dramatically inhibited the survival of various cancers. Notably, TNFα activation of NF-κB was totally impaired after GPR108 knockout. We identified gambogic acid (GA), a natural prenylated xanthone, selectively targeting GPR108. Importantly, GA engaged with GPR108 and promoted its degradation, knockout of GPR108 remarkably blocked molecule inhibitor GA directly and selectively targeting GPR108 for cancer therapy."

disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A

of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis of Novel GPR139

variants identified in several GPCRs associated with obesity and other metabolic diseases, including GPR10