Depletion of GPR108 dramatically inhibited the survival of various cancers. Notably, TNFα activation of NF-κB was totally impaired after GPR108 knockout. We identified gambogic acid (GA), a natural prenylated xanthone, selectively targeting GPR108. Importantly, GA engaged with GPR108 and promoted its degradation, knockout of GPR108 remarkably blocked molecule inhibitor GA directly and selectively targeting GPR108 for cancer therapy."

disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A

of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis of Novel GPR139

2 receptor with selective and nonselective antagonists studied by NMR spectroscopy Up-regulation of GPR139

of the kappa-opioid receptor GPCRs in Neuroscience Research progress on the role of orphan receptor GPR139

amino acid substitution G protein-coupled receptors: from radioligand binding to cellular signaling GPR101

Molecular sensing of mechano- and ligand-dependent adhesion GPCR dissociation GPCR Activation and Signaling GPR101

Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139

Structural and Molecular Insights into GPCR Function Cryo-EM structure of human class C orphan GPCR GPR179

Cholesterol Interactions at the Receptor-Lipid Microenvironment Basal interaction of the orphan receptor GPR101

Insights into GPCR Function Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103

GPCRs in Cardiology, Endocrinology, and Taste G-protein coupled receptor 19 (GPR19) knockout mice display

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses

Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor GPR139