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October 2022 GPR125 (ADGRA3) is an autocleavable adhesion GPCR that traffics with Dlg1 to the basolateral GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating Here, we show that human GPR125 likely undergoes cis-autoproteolysis when expressed in canine kidney Furthermore, in polarized MDCK cells, GPR125 is exclusively recruited to the basolateral domain of the The recruitment likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction

presented this important pre-clinical work at SIRS2022 confirming the ability of the highly selective novel GPR52 important interplay between the adenosinergic and dopaminergic systems and suggests the potential for GPR52

October 2022 GPR15 expressed in T lymphocytes from RA patients is involved in leukocyte chemotaxis to GPR15 is a G protein-coupled receptor (GPCR) located on chromosome 3 and has similarity in its sequence The expression of GPR15 and c10orf99/gpr15l mRNA was analyzed by RT-qPCR. +GPR15+ T cell frequency comparing RA patients versus control subjects by flow cytometry. A higher expression in the mRNA for GPR15 was identified in early RA subjects.

Fellowship in order to investigate and find better ligands for the orphan class A GPCRs , GPR3 , GPR6 , and GPR12

System, Proteomics and Transcriptomics, Receptor Structure, Signaling and Activation Mechanism Adgrg6/Gpr126 of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn GPR124 Biology Tyler Bernadyn Next Generation MBD2 inhibitors for Brain Cancer Therapy Jesse Stillwell Adgrg6/Gpr126 Alex Torrelli-Diljohn on the web The University of Alabama at Birmingham LinkedIn GPR124 Mediates Adhesion

glucocorticoid to mediate its rapid actions, the progesterone and 17-hydroxyprogesterone membrane receptor are GPR126