B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183

October 2022 Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity of GPR183 antagonists as analgesics. These effects are blocked by the selective small molecule GPR183 antagonist, SAE-14. However, the molecular mechanisms engaged downstream of GPR183 in the spinal cord are not known. effects are blocked by the selective GPR183 antagonist SAE-14.

GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer

< GPCR News < GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and Here, we find that GPR143, an atypical GPCR, controls the endosomal sorting complex required for the GPR143 interacts with HRS (an ESCRT-0 Subunit) and promotes its association to cargo proteins, such as GPR143 is elevated in multiple cancers, and quantitative proteomic and RNA profiling of exosomes in human cancer cell lines showed that the GPR143-ESCRT pathway promotes secretion of exosomes that carry unique

Here, we demonstrate that GPR141, an orphan GPCR belonging to the class A receptor family, suppresses High GPR141 messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell However, Gpr141 deficiency exacerbated disease conditions of experimental autoimmune encephalomyelitis Moreover, CD11c+ dendritic cells (DCs) purified from Gpr141 -/- mice increased cytokine production of

Brendan’s PhD project focuses on the orphan GPCR GPR146. This project aims to characterise the molecular pharmacology of GPR146 and to validate the proposed ligands of GPR146 in line with IUPHAR-NC guidelines on deorphanisation of orphan GPCRs.