B-lymphocytes and dendritic cells to interfollicular regions of lymphoid tissues through binding the EBI2 (GPR183

October 2022 Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity of GPR183 antagonists as analgesics. These effects are blocked by the selective small molecule GPR183 antagonist, SAE-14. However, the molecular mechanisms engaged downstream of GPR183 in the spinal cord are not known. effects are blocked by the selective GPR183 antagonist SAE-14.

GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer

GPCR Activation and Signaling Coupling between GPR143 and dopamine D2 receptor is required for selective

GPCR-like receptor to sense noxious heat via Gαq signaling Exploring the Activation Mechanism of the GPR183 Insights into GPCR Function Structure and dynamics of the pyroglutamylated RF-amide peptide QRFP receptor GPR103

PMID: 38412860 GPR133 is hypomethylated and upregulated in decidual macrophages in recurrent spontaneous Dimitris Placantonakis’s identifies extended synaptotagmin 1 as an intracellular interaction partner of GPR133

PTK7 is a positive allosteric modulator of GPR133 signaling in glioblastoma.

Desensitization of G Protein-Coupled Receptor RNA-seq screening and gene function analysis uncover GPR183

this year the transmembrane structures of the aGPCRs ADGRL3/Lphn3, ADGRG1/GPR56, ADGRG5/GPR114, ADGRD1/GPR133