CCR4La, CCR4Lc, CCR12a1, CCR12a2, and CCR12b) in largemouth bass (Micropterus salmoides) The pyruvate-GPR31

GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival. The clinical significance of GPR39 in colon cancer has never been reported. Materials: In our study, we compared GPR39 expression between colon cancers and tumor-adjacent tissues The clinical significance of GPR39 was evaluated by analyzing the correlations with clinicopathological The prognostic significance of GPR39 was estimated with univariate and multivariate analyses.

September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer mediate intracellular pathway bias "Within the intestine, the human G protein-coupled receptor (GPCR) GPR35 GPR35 is known to be expressed as two distinct isoforms that differ only in the length of their extracellular Additionally, we employed optical assays in living cells to thoroughly profile both GPR35 isoforms for ligands that selectively modulate GPR35-transducer interactions and allow for mechanism-based therapies

< GPCR News < GPCRs in Oncology and Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite Here, we show that GPR31, which is activated by the gut bacterial metabolite pyruvate, is specifically Accordingly, GPR31 activation via pyruvate enhances the fundamental function of cDC1 by allowing efficient Hiroki Ikeuchi, Eiji Umemoto, Atsushi Kumanogoh, Kiyoshi Takeda Tags G protein-coupled receptors , GPR31

We detected the expression of GPR37 in NSCLC tissues and cell lines. The study explored the influence of GPR37 on tumor cell proliferation. Furthermore, we examined the effects of GPR37 on tumor cell apoptosis and invasion. Most importantly, we investigated whether GPR37 affects cisplatin-induced drug resistance in NSCLC. Knockdown of GPR37 significantly inhibits the occurrence and development of NSCLC.

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled estrogen receptor (GPER)/GPR30 forms in MCF7 breast cancer cells Published date January 10, 2024 Abstract "G protein-coupled receptor 30 (GPR30 GPR30 constitutively and PDZ-dependently inhibits β1AR-mediated cAMP production. Deleting the GPR30 C-terminal PDZ motif (-SSAV) does not interfere with the receptor complex, indicating These results argue that GPR30 and β1AR form a PDZ-independent complex in MCF7 cells through which GPR30