GPR39 is a GPCR which can interact with Zn and modulate the colonocytes' survival. The clinical significance of GPR39 in colon cancer has never been reported. Materials: In our study, we compared GPR39 expression between colon cancers and tumor-adjacent tissues The clinical significance of GPR39 was evaluated by analyzing the correlations with clinicopathological The prognostic significance of GPR39 was estimated with univariate and multivariate analyses.

Selenomethionine Promotes Milk Protein and Fat Synthesis and Proliferation of Mammary Epithelial Cells through the GPR37

Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37

in Post-COVID ME/CFS Patients with Elevated ß2-Adrenergic Receptor Autoantibodies-An Interim Report GPR37

September 2022 Isoforms of GPR35 have distinct extracellular N-termini that allosterically modify receptor-transducer mediate intracellular pathway bias "Within the intestine, the human G protein-coupled receptor (GPCR) GPR35 GPR35 is known to be expressed as two distinct isoforms that differ only in the length of their extracellular Additionally, we employed optical assays in living cells to thoroughly profile both GPR35 isoforms for ligands that selectively modulate GPR35-transducer interactions and allow for mechanism-based therapies

August 2022 GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates GPR3 is unique in its ability to constitutively activate the Gαs protein without a ligand, which elevates Our earlier reports suggested that GPR3 enhances both neurite outgrowth and neuronal survival. GPR3 was relatively highly expressed in retinal ganglion cells (RGCs). Evaluation of the effect of GPR3 on axonal regeneration using GPR3 knockout mice revealed that GPR3 in

Our previous work demonstrated that GPR3-mediated β-arrestin signaling modulates amyloid-β (Aβ) generation in vitro and that Gpr3 deficiency ameliorates Aβ pathology in vivo. However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior consequences of selective elimination of GPR3-mediated β-arrestin signaling in vivo. In contrast to Gpr3-deficient mice, G protein-biased GPR3 mice do not display elevated anxiety levels

Understanding of the Palmitoylation of Go Protein in the Allosteric Regulation of Adhesion Receptor GPR97 The orphan receptor GPR97, activated by glucocorticoid stress hormones, is a prototypical aGPCR. Hence, we performed extensive large-scale molecular dynamics (MD) simulations of the GPR97-Go complex conformational landscapes analyzed by Markov state models revealed that the overall conformation of GPR97 and increase the affinity of the ligand for GPR97.

Kathleen M Caron and her team studied the GPER/GPR30 complex with β1-adrenergic receptor and AKAP5 in receptors in auditory neurons GPCRs in Oncology and Immunology G protein-coupled estrogen receptor (GPER)/GPR30

interact with a set of genomically related transmembrane receptors, like C5aR1 (CD88, C5aR) and C5aR2 (GPR77

Schihada and his lab team developed fluorescent analogues for real-time binding studies of orphan GPCR GPR3 Development of Fluorescent AF64394 Analogues Enables Real-Time Binding Studies for the Orphan Class A GPCR GPR3

Belousoff et al. for their work on Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor GPR3 histamine H3 receptor isoforms Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3

Immunotherapy Sosei Heptares Regains Full Ownership from GSK of HTL0027477, a Clinic-ready, First-in-Class Oral GPR35

GPR97 deficiency ameliorates renal interstitial fibrosis in mouse hypertensive nephropathy.

Discovery of (S)-3-(4-(benzyloxy)phenyl)-2-(2-phenoxyacetamido)propanoic acid derivatives as a new class of GPR34

serotonin receptor Structural and Molecular Insights into GPCR Function Cryo-EM structures of human GPR34

Cryo-EM structure of G-protein-coupled receptor GPR17 in complex with inhibitory G protein.

GPCRs in Cardiology, Endocrinology, and Taste GPR97 deficiency ameliorates renal interstitial fibrosis

Expands with New Wet Laboratory Space in Vancouver   ThirtyFiveBio receives grant to continue work on GPR35

Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy GPR97

inhibition in rotenone-mediated parkinsonism in rats: Modulation of dopamine D3 receptor Satellite glial GPR37L1

Randy Hall's study: GPR37L1's role in shaping cortical astrocytes during development Dr. dopaminergic neuron damage in Parkinson's disease mouse model through activating GHS-R1a/D2R heterodimers GPR37L1

GPR37L1 controls maturation and organization of cortical astrocytes during development.